WAY-163909 [Ligand Id: 229] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL1628670 (WAY-163909) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | Binding affinity to 5HT2C receptor (unknown origin) | B | 7.98 | pKi | 10.5 | nM | Ki | Bioorg Med Chem Lett (2020) 30: 126929-126929 [PMID:31952960] |
| GtoPdb | - | - | 8 | pKi | 10 | nM | Ki | J Pharmacol Exp Ther (2005) 313: 862-9 [PMID:15705738] |
| ChEMBL | Displacement of [125I]DOI from human 5-HT2C receptor | B | 8 | pKi | 10 | nM | Ki | J Med Chem (2014) 57: 1488-1494 [PMID:24491146] |
| ChEMBL | Agonist activity at human 5-HT2C receptor assessed as stimulation of Ca2+ mobilization | F | 8.1 | pEC50 | 8 | nM | EC50 | J Med Chem (2014) 57: 1488-1494 [PMID:24491146] |
| ChEMBL | Agonist activity at 5HT2C receptor (unknown origin) relative to control | B | 8.1 | pEC50 | 8 | nM | EC50 | J Med Chem (2015) 58: 1992-2002 [PMID:25633969] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
