YM 471 [Ligand Id: 2205] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL307483 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| V1A receptor/Vasopressin V1a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288] | ||||||||
| GtoPdb | - | - | 9.2 | pKi | - | - | - | Br J Pharmacol (2001) 133: 746-54 [PMID:11429400] |
| ChEMBL | Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligand | B | 9.21 | pKi | 0.62 | nM | Ki | J Med Chem (2002) 45: 2589-2598 [PMID:12036368] |
| V1A receptor/Vasopressin V1a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2868] [GtoPdb: 366] [UniProtKB: P30560] | ||||||||
| ChEMBL | Evaluated for the binding affinity towards vasopressin (V1A) receptor in rat liver membrane using [3H]AVP as radioligand | B | 9.21 | pKi | 0.62 | nM | Ki | Bioorg Med Chem Lett (2002) 12: 229-232 [PMID:11755361] |
| ChEMBL | Binding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liver | B | 9.8 | pKi | 0.16 | nM | Ki | J Med Chem (2002) 45: 2589-2598 [PMID:12036368] |
| V2 receptor/Vasopressin V2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518] | ||||||||
| GtoPdb | - | - | 8.9 | pKi | - | - | - | Br J Pharmacol (2001) 133: 746-54 [PMID:11429400] |
| ChEMBL | Binding affinity at cloned human Vasopressin V2 receptor stably expressed in CHO cells, using [3H]AVP as radioligand | B | 8.92 | pKi | 1.19 | nM | Ki | J Med Chem (2002) 45: 2589-2598 [PMID:12036368] |
| V2 receptor/Vasopressin V2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3766] [GtoPdb: 368] [UniProtKB: Q00788] | ||||||||
| ChEMBL | Evaluated for the binding affinity towards vasopressin (V2) receptor in rat kidney membrane using [3H]AVP as radioligand | B | 8.92 | pKi | 1.19 | nM | Ki | Bioorg Med Chem Lett (2002) 12: 229-232 [PMID:11755361] |
| ChEMBL | Binding affinity at Vasopressin V2 receptor, performed using [3H]AVP on rat kidney | B | 9.11 | pKi | 0.77 | nM | Ki | J Med Chem (2002) 45: 2589-2598 [PMID:12036368] |
| V1B receptor in Human [GtoPdb: 367] [UniProtKB: P47901] | ||||||||
| GtoPdb | - | - | 4.8 | pKi | - | - | - | Br J Pharmacol (2001) 133: 746-54 [PMID:11429400] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
