L023103 [Ligand Id: 2194] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL445816
Created with Highcharts 10.3.3ValuesChart context menuOxytocin receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd RatpKi RatpIC50 RatpEC50 Rat0246810Highcharts.com
  • V1A receptor/Vasopressin V1a receptor in Human [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288]
Created with Highcharts 10.3.3ValuesChart context menuVasopressin V1a receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • V1B receptor/Vasopressin V1b receptor in Human [ChEMBL: CHEMBL1921] [GtoPdb: 367] [UniProtKB: P47901]
Created with Highcharts 10.3.3ValuesChart context menuVasopressin V1b receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • V2 receptor/Vasopressin V2 receptor in Human [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518]
Created with Highcharts 10.3.3ValuesChart context menuVasopressin V2 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
OT receptor/Oxytocin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2049] [GtoPdb: 369] [UniProtKB: P30559]
ChEMBL Displacement of [125I]OVTA antagonist from human oxytocin receptor expressed in HEK293-EBNA cells B 9.19 pKi 0.65 nM Ki J Med Chem (2005) 48: 7882-7905 [PMID:16302826]
ChEMBL Displacement of [3H]-oxytocin from human oxytocin receptor expressed in HEK293-EBNA cells B 9.19 pKi 0.65 nM Ki J Med Chem (2010) 53: 6525-6538 [PMID:20550119]
GtoPdb - - 9.2 pKi - - - J Med Chem (2005) 48: 7882-905 [PMID:16302826]
ChEMBL Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells F 7.85 pIC50 14 nM IC50 J Med Chem (2005) 48: 7882-7905 [PMID:16302826]
OT receptor/Oxytocin receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3996] [GtoPdb: 369] [UniProtKB: P70536]
ChEMBL Displacement of [125I]OVTA antagonist from rat oxytocin receptor expressed in HEK293-EBNA cells B 9.17 pKi 0.67 nM Ki J Med Chem (2005) 48: 7882-7905 [PMID:16302826]
ChEMBL Displacement of [3H]-oxytocin from rat oxytocin receptor expressed in HEK293-EBNA cells B 9.17 pKi 0.67 nM Ki J Med Chem (2010) 53: 6525-6538 [PMID:20550119]
GtoPdb - - 9.2 pKi - - - J Med Chem (2005) 48: 7882-905 [PMID:16302826]
V1A receptor/Vasopressin V1a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288]
ChEMBL Displacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells B 7.38 pKi 42 nM Ki J Med Chem (2005) 48: 7882-7905 [PMID:16302826]
GtoPdb - - 7.4 pKi - - - J Med Chem (2005) 48: 7882-905 [PMID:16302826]
ChEMBL Displacement of [3H]vasopressin from vasopressin V1a receptor in human liver tissue B 9.19 pKi 0.65 nM Ki J Med Chem (2010) 53: 6525-6538 [PMID:20550119]
V1B receptor/Vasopressin V1b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1921] [GtoPdb: 367] [UniProtKB: P47901]
ChEMBL Displacement of [3H]vasopressin from human vasopressin V1b receptor expressed in CHO cells B 5.45 pKi 3539 nM Ki J Med Chem (2010) 53: 6525-6538 [PMID:20550119]
V2 receptor/Vasopressin V2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518]
ChEMBL Displacement of [3H]vasopressin from vasopressin V2 receptor in human kidney tissue B 9.17 pKi 0.67 nM Ki J Med Chem (2010) 53: 6525-6538 [PMID:20550119]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]