desmopressin [Ligand Id: 2182] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL264448
  • V1A receptor in Human [GtoPdb: 366] [UniProtKB: P37288]
  • V1A receptor in Rat [GtoPdb: 366] [UniProtKB: P30560]
There should be some charts here, you may need to enable JavaScript!
  • V1B receptor in Human [GtoPdb: 367] [UniProtKB: P47901]
  • V1B receptor in Rat [GtoPdb: 367] [UniProtKB: P48974]
There should be some charts here, you may need to enable JavaScript!
  • V2 receptor in Human [GtoPdb: 368] [UniProtKB: P30518]
  • V2 receptor in Rat [GtoPdb: 368] [UniProtKB: Q00788]
There should be some charts here, you may need to enable JavaScript!
  • OT receptor in Human [GtoPdb: 369] [UniProtKB: P30559]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
V1A receptor in Human [GtoPdb: 366] [UniProtKB: P37288]
GtoPdb - - 7.7 pKi - - - Br J Pharmacol (1998) 125: 1463-70 [PMID:9884074];
J Biol Chem (1997) 272: 26536-44 [PMID:9334232];
Br J Pharmacol (2000) 129: 1700-6 [PMID:10780976];
Endocrinology (1997) 138: 4109-22 [PMID:9322919];
J Med Chem (2004) 47: 2375-2388 [PMID:15084136];
Biochem Pharmacol (1997) 53: 1711-1717 [PMID:9264324]
V1A receptor in Rat [GtoPdb: 366] [UniProtKB: P30560]
GtoPdb - - 5.6 pKi - - - EMBO J (1995) 14: 2176-82 [PMID:7774575]
V1B receptor in Human [GtoPdb: 367] [UniProtKB: P47901]
GtoPdb - - 8.2 pKi - - - Br J Pharmacol (2000) 129: 1700-6 [PMID:10780976];
Endocrinology (1997) 138: 4109-22 [PMID:9322919];
J Med Chem (2004) 47: 2375-2388 [PMID:15084136];
Biochem Pharmacol (1997) 53: 1711-1717 [PMID:9264324]
V1B receptor in Rat [GtoPdb: 367] [UniProtKB: P48974]
GtoPdb - - 8 pKi - - - Biochem Pharmacol (1997) 53: 1711-1717 [PMID:9264324]
V2 receptor in Human [GtoPdb: 368] [UniProtKB: P30518]
GtoPdb - - 8.6 pKi 2.5 nM Ki J Med Chem (2004) 47: 2375-2388 [PMID:15084136];
EMBO J (1995) 14: 2176-82 [PMID:7774575];
J Biol Chem (1998) 273: 29462-8 [PMID:9792651];
Br J Pharmacol (2000) 129: 1700-6 [PMID:10780976];
Biochem Pharmacol (1997) 53: 1711-1717 [PMID:9264324];
Kidney Int (2000) 58: 1613-22 [PMID:11012895];
Br J Pharmacol (1998) 125: 1463-70 [PMID:9884074];
Endocrinology (1997) 138: 4109-22 [PMID:9322919]
V2 receptor in Rat [GtoPdb: 368] [UniProtKB: Q00788]
GtoPdb - - 8.7 pKi - - - J Biol Chem (1998) 273: 29462-8 [PMID:9792651]
OT receptor in Human [GtoPdb: 369] [UniProtKB: P30559]
GtoPdb - - 7.6 pKi - - - EMBO J (1995) 14: 2176-82 [PMID:7774575];
Life Sci (1995) 57: 2253-61 [PMID:7475979]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]