AC-7954 [Ligand Id: 2151] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL192359 (AC-7954) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| UT receptor/Urotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3764] [GtoPdb: 365] [UniProtKB: Q9UKP6] | ||||||||
| GtoPdb | - | - | 6.6 | pKi | - | - | - |
J Med Chem (2002) 45: 4950-3 [PMID:12408704]; Bioorg Med Chem (2005) 13: 3057-68 [PMID:15781415] |
| ChEMBL | Activity against human urotensin-2 receptor expressed in NIH3T3 cells | B | 5.95 | pEC50 | 1122.02 | nM | EC50 | J Med Chem (2006) 49: 2232-2240 [PMID:16570919] |
| ChEMBL | Agonist activity against human urotensin 2 receptor expressed in human NIH373 cells assessed as beta-galactosidase activity after 5 days by R-SAT assay | F | 5.95 | pEC50 | >=1122.02 | nM | EC50 | Bioorg Med Chem (2009) 17: 4657-4665 [PMID:19481466] |
| ChEMBL | Agonist activity against human urotensin 2 receptor expressed in human NIH373 cells assessed as beta-galactosidase activity after 5 days by R-SAT assay | F | 5.95 | pEC50 | 1122.02 | nM | EC50 | Bioorg Med Chem (2010) 18: 4844-4854 [PMID:20570157] |
| ChEMBL | Agonist activity for human Urotensin 2 receptor | F | 6.52 | pEC50 | 300 | nM | EC50 | J Med Chem (2005) 48: 2480-2492 [PMID:15801838] |
| ChEMBL | Agonist activity at human urotensin 2 expressed in CHO cells by FLIPR | F | 6.6 | pEC50 | 250 | nM | EC50 | J Med Chem (2010) 53: 2695-2708 [PMID:20043680] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
