eledoisin [Ligand Id: 2086] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL373569 (ELD 950, ELD-950, Eledoisin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| NK3 receptor/Neurokinin 3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4429] [GtoPdb: 362] [UniProtKB: P29371] | ||||||||
| GtoPdb | - | - | 6.6 | pIC50 | 264.2 | nM | IC50 |
J Biol Chem (1996) 271: 20250-7 [PMID:8702757]; FEBS Lett (1992) 299: 90-5 [PMID:1312036] |
| ChEMBL | Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysis | B | 7.02 | pIC50 | 96 | nM | IC50 | Bioorg Med Chem (2013) 21: 2413-2417 [PMID:23473945] |
| ChEMBL | Activity at human NK3 receptor expressed in CHO cells assessed as increase in inositol phosphate generation | F | 8.18 | pEC50 | 6.6 | nM | EC50 | Bioorg Med Chem Lett (2006) 16: 5752-5756 [PMID:16950617] |
| ChEMBL | Activity at human NK3 receptor assessed as stimulation of inositol phosphate generation in CHO cells | F | 8.24 | pEC50 | 5.7 | nM | EC50 | Bioorg Med Chem Lett (2006) 16: 5748-5751 [PMID:16950620] |
| ChEMBL | Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM | F | 9.66 | pEC50 | 0.22 | nM | EC50 | Bioorg Med Chem (2013) 21: 2413-2417 [PMID:23473945] |
| NK1 receptor in Human [GtoPdb: 360] [UniProtKB: P25103] | ||||||||
| GtoPdb | - | - | 8.6 | pIC50 | - | - | - | J Biol Chem (1996) 271: 20250-7 [PMID:8702757] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
