ChEMBL ligand: CHEMBL445102 (L-741626)
D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] There should be some charts here, you may need to enable JavaScript!
D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] There should be some charts here, you may need to enable JavaScript!
D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] There should be some charts here, you may need to enable JavaScript!
D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] There should be some charts here, you may need to enable JavaScript!
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] There should be some charts here, you may need to enable JavaScript!
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] There should be some charts here, you may need to enable JavaScript!
Sigma-1 receptor in Guinea pig [ChEMBL: CHEMBL4153] [UniProtKB: Q60492] There should be some charts here, you may need to enable JavaScript!
5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
ChEMBL	Displacement of [3H]SCH23390 from dopamine D1 receptor	B	6.14	pKi	722	nM	Ki	J Med Chem (2008) 51: 6095-6109 [PMID:18774793]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL	Displacement of [125I]IABN from human dopamine D2L receptor expressed in HEK293 cells	B	7.95	pKi	11.2	nM	Ki	Bioorg Med Chem Lett (2007) 17: 745-749 [PMID:17095222]
ChEMBL	Displacement of [125I]IABN from human dopamine D2L receptor expressed in HEK293 cells	B	7.95	pKi	11.2	nM	Ki	J Med Chem (2008) 51: 6095-6109 [PMID:18774793]
ChEMBL	Displacement of [3H]N-methylspiperone from human dopamine D2 receptor by liquid scintillation counting	B	7.95	pKi	11.2	nM	Ki	Bioorg Med Chem (2009) 17: 1716-1723 [PMID:19155177]
ChEMBL	Displacement of [125I]ABN from human dopamine D2 long receptor expressed in HEK293 cells after 60 mins by gamma counting	B	8	pKi	10	nM	Ki	Bioorg Med Chem (2010) 18: 5291-5300 [PMID:20542439]
ChEMBL	Displacement of [3H]methylspiperone from human D2L receptor expressed in HEK cell membrane after 90 mins by scintillation counting analysis	B	8.12	pKi	7.5	nM	Ki	J Med Chem (2014) 57: 3450-3463 [PMID:24666157]
GtoPdb	-	-	8.5	pKi	-	-	-	J Med Chem (1996) 39: 1941-2 [PMID:8642550]; Bioorg Med Chem Lett (2007) 17: 745-9 [PMID:17095222]
ChEMBL	Binding affinity towards cloned human Dopamine receptor D2 stably expressed in CHO cells was evaluated using [3H]spiperone as radioligand	B	8.62	pKi	2.4	nM	Ki	J Med Chem (1996) 39: 1941-1942 [PMID:8642550]
ChEMBL	Antagonist activity at dopamine D2 receptor	F	8.35	pIC50	4.46	nM	IC50	J Med Chem (2008) 51: 6095-6109 [PMID:18774793]
ChEMBL	Antagonist activity at human dopamine D2 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	F	8.35	pEC50	4.46	nM	EC50	Bioorg Med Chem Lett (2007) 17: 745-749 [PMID:17095222]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
ChEMBL	Displacement of [125I]IABN from human dopamine D3 receptor expressed in HEK293 cells	B	6.79	pKi	163	nM	Ki	Bioorg Med Chem Lett (2007) 17: 745-749 [PMID:17095222]
ChEMBL	Displacement of [125I]IABN from human dopamine D3 receptor expressed in HEK293 cells	B	6.79	pKi	163	nM	Ki	J Med Chem (2008) 51: 6095-6109 [PMID:18774793]
ChEMBL	Displacement of [125I]ABN from human dopamine D3 receptor expressed in HEK293 cells after 60 mins by gamma counting	B	6.98	pKi	104	nM	Ki	Bioorg Med Chem (2010) 18: 5291-5300 [PMID:20542439]
ChEMBL	Binding affinity towards cloned human Dopamine receptor D3 stably expressed in CHO cells was evaluated using [3H]spiperone as radioligand	B	7	pKi	100	nM	Ki	J Med Chem (1996) 39: 1941-1942 [PMID:8642550]
ChEMBL	Compound was measured for its ability to compete with [3H]spiperone binding to the human Dopamine receptor D3 transfected in CHO cells	B	7.06	pKi	87	nM	Ki	J Med Chem (2003) 46: 4377-4392 [PMID:14521403]
ChEMBL	Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cells	B	7.22	pKi	60	nM	Ki	J Med Chem (2003) 46: 4377-4392 [PMID:14521403]
ChEMBL	Displacement of [3H]methylspiperone from human D3 receptor expressed in HEK293 cell membrane after 90 mins by scintillation counting analysis	B	7.31	pKi	48.6	nM	Ki	J Med Chem (2014) 57: 3450-3463 [PMID:24666157]
ChEMBL	Antagonist activity at dopamine D3 receptor	F	7.04	pIC50	90.4	nM	IC50	J Med Chem (2008) 51: 6095-6109 [PMID:18774793]
ChEMBL	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	F	7.04	pEC50	90.4	nM	EC50	Bioorg Med Chem Lett (2007) 17: 745-749 [PMID:17095222]
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL	Displacement of [125I]DOI from human dopamine D4 receptor by liquid scintillation counting	B	5.82	pKi	1520.7	nM	Ki	Bioorg Med Chem (2009) 17: 1716-1723 [PMID:19155177]
ChEMBL	Displacement of [125I]IABN from human dopamine D4 receptor expressed in HEK293 cells	B	5.82	pKi	1520	nM	Ki	Bioorg Med Chem Lett (2007) 17: 745-749 [PMID:17095222]
ChEMBL	Displacement of [125I]IABN from human dopamine D4 receptor	B	5.96	pKi	1100	nM	Ki	J Med Chem (2008) 51: 6095-6109 [PMID:18774793]
ChEMBL	Displacement of [125I]ABN from human dopamine D4 receptor expressed in HEK293 cells after 60 mins by gamma counting	B	6.35	pKi	449	nM	Ki	Bioorg Med Chem (2010) 18: 5291-5300 [PMID:20542439]
ChEMBL	Binding affinity towards cloned human Dopamine receptor D4 stably expressed in CHO cells was evaluated using [3H]spiperone as radioligand	B	6.66	pKi	220	nM	Ki	J Med Chem (1996) 39: 1941-1942 [PMID:8642550]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay	F	5.1	pIC50	7943.28	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay	F	5.1	pIC50	7943.28	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay	F	5.3	pIC50	5011.87	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay	F	5.4	pIC50	3981.07	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL	Displacement of [3H]8OH-DPAT from 5HT1A receptor	B	5.2	pKi	6300	nM	Ki	J Med Chem (2008) 51: 6095-6109 [PMID:18774793]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL	Displacement of [3H]ketanserin from 5HT2A receptor	B	6.16	pKi	695	nM	Ki	J Med Chem (2008) 51: 6095-6109 [PMID:18774793]
GtoPdb	-	-	6.5	pKi	-	-	-	J Pharmacol Exp Ther (2000) 293: 1048-62 [PMID:10869410]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL	Displacement of [3H]mesulergine from 5HT2C receptor	B	5.18	pKi	6570	nM	Ki	J Med Chem (2008) 51: 6095-6109 [PMID:18774793]
Sigma-1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4153] [UniProtKB: Q60492]
ChEMBL	Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain homogenates after 1 hr by liquid scintillation counting	B	7.71	pKi	19.3	nM	Ki	Bioorg Med Chem (2010) 18: 5291-5300 [PMID:20542439]
5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595]
GtoPdb	-	-	6.2	pKi	-	-	-	J Pharmacol Exp Ther (2000) 293: 1048-62 [PMID:10869410]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]