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ChEMBL ligand: CHEMBL574817 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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P2Y purinoceptor 1 in Turkey (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5720] [UniProtKB: P49652] | ||||||||
ChEMBL | In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes. | F | 4.83 | pIC50 | 14900 | nM | IC50 | J Med Chem (1999) 42: 1625-1638 [PMID:10229631] |
ChEMBL | Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATP | F | 5.38 | pIC50 | 4190 | nM | IC50 | J Med Chem (1998) 41: 183-190 [PMID:9457242] |
ChEMBL | Concentration at which 50% of the maximal effect (stimulation of PLC at P2Y1 receptor in the turkey erythrocyte membranes) is reached | F | 5.63 | pEC50 | 2340 | nM | EC50 | J Med Chem (1999) 42: 1625-1638 [PMID:10229631] |
ChEMBL | Agonist activity at P2Y1 receptor measured as capacity to stimulate 50% phospholipase C in turkey erythrocyte membranes | F | 5.89 | pEC50 | 1280 | nM | EC50 | J Med Chem (1998) 41: 183-190 [PMID:9457242] |
P2Y1 receptor in Human [GtoPdb: 323] [UniProtKB: P47900] | ||||||||
GtoPdb | - | - | 5.6 | pEC50 | - | - | - | Mol Pharmacol (1996) 50: 1323-9 [PMID:8913364] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]