A2P5P [Ligand Id: 1717] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1161861 (Adenosine 2',5'-Diphosphate) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Ketopantoate reductase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4855] [UniProtKB: P0A9J4] | ||||||||
| ChEMBL | Binding affinity to Escherichia coli KPR | B | 4 | pKd | 100000 | nM | Kd | J Med Chem (2006) 49: 4992-5000 [PMID:16884311] |
| P2Y purinoceptor 1 in Turkey (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5720] [UniProtKB: P49652] | ||||||||
| ChEMBL | Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATP | F | 5.07 | pIC50 | 8460 | nM | IC50 | J Med Chem (1998) 41: 183-190 [PMID:9457242] |
| ChEMBL | Agonist activity at P2Y1 receptor measured as capacity to stimulate 50% phospholipase C in turkey erythrocyte membranes | F | 5.86 | pEC50 | 1370 | nM | EC50 | J Med Chem (1998) 41: 183-190 [PMID:9457242] |
| P2Y1 receptor in Human [GtoPdb: 323] [UniProtKB: P47900] | ||||||||
| GtoPdb | - | - | 5.8 | pEC50 | - | - | - | Mol Pharmacol (1996) 50: 1323-9 [PMID:8913364] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
