SB-408124 [Ligand Id: 1704] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1334465 (SB-408124) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] | ||||||||
| ChEMBL | Binding affinity to dopamine D1 receptor (unknown origin) | B | 5.75 | pKi | 1780 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 4761-4769 [PMID:23891187] |
| OX1 receptor/Orexin receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5113] [GtoPdb: 321] [UniProtKB: O43613] | ||||||||
| ChEMBL | Binding affinity to OX1 receptor | B | 7.57 | pKd | 26.92 | nM | Kd | J Med Chem (2009) 52: 891-903 [PMID:19199652] |
| GtoPdb | - | - | 7 | pKi | 100 | nM | Ki | J Pharmacol Exp Ther (2015) 352: 590-601 [PMID:25583879] |
| GtoPdb | - | - | 7.5 | pKi | 31.6 | nM | Ki | Mol Pharmacol (2009) 76: 618-31 [PMID:19542319] |
| ChEMBL | Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-type OX1 receptor expressed in baculovirus infected Sf21 insect cell membranes measured after 90 mins by liquid scintillation counting method | B | 7.6 | pKi | 25.12 | nM | Ki | J Med Chem (2020) 63: 1528-1543 [PMID:31860301] |
| ChEMBL | Binding affinity to orexin receptor 1 (unknown origin) | B | 7.66 | pKi | 22 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 4761-4769 [PMID:23891187] |
| OX1 receptor in Rat [GtoPdb: 321] [UniProtKB: P56718] | ||||||||
| GtoPdb | - | - | 6.4 | pKi | 400 | nM | Ki | J Pharmacol Exp Ther (2015) 352: 590-601 [PMID:25583879] |
| OX2 receptor/Orexin receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4792] [GtoPdb: 322] [UniProtKB: O43614] | ||||||||
| GtoPdb | - | - | 5 | pKi | <10000 | nM | Ki | J Pharmacol Exp Ther (2015) 352: 590-601 [PMID:25583879] |
| GtoPdb | - | - | 5.7 | pKi | <2000 | nM | Ki | Mol Pharmacol (2009) 76: 618-31 [PMID:19542319] |
| ChEMBL | Binding affinity to orexin receptor 2 (unknown origin) | B | 5.85 | pKi | 1405 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 4761-4769 [PMID:23891187] |
| ChEMBL | Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-type OX2 receptor expressed in baculovirus infected Sf21 insect cell membranes measured after 90 mins by liquid scintillation counting method | B | 6.1 | pKi | 794.33 | nM | Ki | J Med Chem (2020) 63: 1528-1543 [PMID:31860301] |
| 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
| ChEMBL | Binding affinity to 5HT2B receptor (unknown origin) | B | 6.49 | pKi | 320 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 4761-4769 [PMID:23891187] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
