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ChEMBL ligand: CHEMBL559569 (SB-612111) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
ChEMBL | Displacement of [3H]diprenorphine from human cloned delta type opioid receptor expressed in CHO cell membranes by scintillation counter | B | 6.4 | pKi | >400 | nM | Ki | J Med Chem (2012) 55: 4955-4967 [PMID:22541041] |
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
ChEMBL | Displacement of [3H]diprenorphine from human cloned kappa type opioid receptor expressed in CHO cell membranes by scintillation counter | B | 6.4 | pKi | >400 | nM | Ki | J Med Chem (2012) 55: 4955-4967 [PMID:22541041] |
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
ChEMBL | Displacement of [3H]diprenorphine from human cloned mu type opioid receptor expressed in CHO cell membranes by scintillation counter | B | 6.4 | pKi | >400 | nM | Ki | J Med Chem (2012) 55: 4955-4967 [PMID:22541041] |
ChEMBL | Displacement of [3H]DAMGO from recombinant human mu opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting method | B | 7.24 | pKi | 58 | nM | Ki | J Med Chem (2016) 59: 7011-7028 [PMID:26878436] |
NOP receptor/Nociceptin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146] | ||||||||
ChEMBL | Displacement of [3H]nociceptin from recombinant human nociceptin opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting method | B | 9.48 | pKi | 0.33 | nM | Ki | J Med Chem (2016) 59: 7011-7028 [PMID:26878436] |
GtoPdb | - | - | 9.5 | pKi | - | - | - |
J Pharmacol Exp Ther (2004) 308: 454-61 [PMID:14593080]; J Pharmacol Exp Ther (2007) 321: 961-7 [PMID:17329552] |
ChEMBL | Displacement of [3H]Nociceptin from human recombinant NOP receptor expressed in CHO cells by scintillation counter | B | 9.6 | pKi | 0.25 | nM | Ki | J Med Chem (2012) 55: 4955-4967 [PMID:22541041] |
ChEMBL | Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation counting | B | 9.6 | pKi | 0.25 | nM | Ki | J Med Chem (2011) 54: 2687-2700 [PMID:21438532] |
GtoPdb | - | - | 9.7 | pIC50 | - | - | - |
J Pharmacol Exp Ther (2004) 308: 454-61 [PMID:14593080]; J Pharmacol Exp Ther (2007) 321: 961-7 [PMID:17329552] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]