ChEMBL ligand: CHEMBL982 (ORF-11676, JF-1, Selincro, Nalmefene, SRD174, ORF 11676, Nalmetrene, SRD-174, JKB-121, ORF-1167, ORF 1167, Nalmefeno)
δ receptor/Delta-type opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] δ receptor/Delta-type opioid receptor in Rat [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa-type opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] Kappa-type opioid receptor in Guinea pig [ChEMBL: CHEMBL3952] [UniProtKB: P41144] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu-type opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] μ receptor/Mu-type opioid receptor in Rat [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta-type opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Activity at human delta opioid receptor by [35S]GTPgammaS binding assay	F	9.04	pKd	0.91	nM	Kd	J Med Chem (2008) 51: 1913-1924 [PMID:18298057]
ChEMBL	Displacement of [3H]naltrindole from human delta-opioid receptor expressed in CHO cell membranes after 3 hrs by scintillation counting	B	7.8	pKi	16	nM	Ki	J Med Chem (2016) 59: 8712-8756 [PMID:27299736]
ChEMBL	Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cells	B	7.88	pKi	13.26	nM	Ki	J Med Chem (2008) 51: 1913-1924 [PMID:18298057]
ChEMBL	Displacement of [3H]DPDPE from delta opioid receptor expressed in HEK293 cells by visible spectrophotometry	B	7.88	pKi	13.26	nM	Ki	Bioorg Med Chem (2009) 17: 6671-6681 [PMID:19683449]
ChEMBL	Displacement of [3H]Naltrindole form human delta opioid receptor expressed in CHO cells	B	8.03	pKi	9.3	nM	Ki	Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293]
GtoPdb	-	-	8.1	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
ChEMBL	Antagonist activity against human DOR expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation pretreated for 15 mins followed by forskolin addition measured after 30 mins by HitHunter cAMP assay	F	6.9	pIC50	125.89	nM	IC50	J Med Chem (2025) 68: 13057-13074 [PMID:40499097]
δ receptor/Delta-type opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533]
ChEMBL	Binding affinity towards delta-opioid receptor by displacement of [3H]DADL in rat brain homogenates	B	8.47	pKi	3.4	nM	Ki	J Med Chem (1993) 36: 2842-2850 [PMID:8410999]
κ receptor/Kappa-type opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cells	B	8.99	pKi	1.03	nM	Ki	J Med Chem (2008) 51: 1913-1924 [PMID:18298057]
ChEMBL	Displacement of [3H]U69593 from kappa opioid receptor expressed in HEK293 cells by visible spectrophotometry	B	8.99	pKi	1.03	nM	Ki	Bioorg Med Chem (2009) 17: 6671-6681 [PMID:19683449]
GtoPdb	-	-	9.5	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
ChEMBL	Displacement of [3H]U69593 form human kappa opioid receptor expressed in CHO cells	B	9.92	pKi	0.12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293]
ChEMBL	Displacement of [3H]U69,593 from human kappa-opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting	B	10.08	pKi	0.08	nM	Ki	J Med Chem (2016) 59: 8712-8756 [PMID:27299736]
ChEMBL	Antagonist activity against human KOR expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation pretreated for 15 mins followed by forskolin addition measured after 30 mins by HitHunter cAMP assay	F	5.12	pIC50	7600	nM	IC50	J Med Chem (2025) 68: 13057-13074 [PMID:40499097]
ChEMBL	Antagonist activity against human KOR expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation pretreated for 15 mins followed by forskolin addition measured after 30 mins by HitHunter cAMP assay	F	8.1	pIC50	7.94	nM	IC50	J Med Chem (2025) 68: 13057-13074 [PMID:40499097]
Kappa-type opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144]
ChEMBL	Binding affinity towards kappa opioid receptor by displacement of [3H]EKC in guinea pig cortical tissue	B	8.7	pKi	2	nM	Ki	J Med Chem (1993) 36: 2842-2850 [PMID:8410999]
μ receptor/Mu-type opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Activity at human mu opioid receptor by [35S]GTPgammaS binding assay	F	9.53	pKd	0.3	nM	Kd	J Med Chem (2008) 51: 1913-1924 [PMID:18298057]
ChEMBL	Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells	B	9.04	pKi	0.91	nM	Ki	J Med Chem (2008) 51: 1913-1924 [PMID:18298057]
ChEMBL	Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cells by visible spectrophotometry	B	9.04	pKi	0.91	nM	Ki	Bioorg Med Chem (2009) 17: 6671-6681 [PMID:19683449]
ChEMBL	Displacement of [3H]DAMGO form human mu opioid receptor expressed in CHO cells	B	9.36	pKi	0.44	nM	Ki	Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293]
GtoPdb	-	-	9.5	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
ChEMBL	Binding affinity to MOR (unknown origin) assessed as inhibition constant	B	9.52	pKi	0.3	nM	Ki	J Med Chem (2024) 67: 603-619 [PMID:38156970]
ChEMBL	Displacement of [3H]DAMGO from human mu-opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting	B	9.62	pKi	0.24	nM	Ki	J Med Chem (2016) 59: 8712-8756 [PMID:27299736]
ChEMBL	Antagonist activity against human MOR expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation pretreated for 15 mins followed by forskolin addition measured after 30 mins by HitHunter cAMP assay	F	5.68	pIC50	2100	nM	IC50	J Med Chem (2025) 68: 13057-13074 [PMID:40499097]
ChEMBL	Antagonist activity against human MOR expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation pretreated for 15 mins followed by forskolin addition measured after 30 mins by HitHunter cAMP assay	F	8.7	pIC50	2	nM	IC50	J Med Chem (2025) 68: 13057-13074 [PMID:40499097]
μ receptor/Mu-type opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535]
ChEMBL	Binding affinity towards mu-opioid receptor by the displacement of [3H]Nal in rat brain homogenates	B	9.54	pKi	0.29	nM	Ki	J Med Chem (1993) 36: 2842-2850 [PMID:8410999]

ChEMBL data shown on this page come from version 37:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]