ChEMBL ligand: CHEMBL982 (JF-1, JKB-121, Nalmefene, Nalmetrene, ORF 1167, ORF-1167, ORF 11676, ORF-11676, Revex, Selincro, SRD-174, SRD174)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] δ receptor/Delta opioid receptor in Rat [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] Kappa opioid receptor in Guinea pig [ChEMBL: CHEMBL3952] [UniProtKB: P41144] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] μ receptor/Mu opioid receptor in Rat [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Activity at human delta opioid receptor by [35S]GTPgammaS binding assay	F	9.04	pKd	0.91	nM	Kd	J Med Chem (2008) 51: 1913-1924 [PMID:18298057]
ChEMBL	Displacement of [3H]naltrindole from human delta-opioid receptor expressed in CHO cell membranes after 3 hrs by scintillation counting	B	7.8	pKi	16	nM	Ki	J Med Chem (2016) 59: 8712-8756 [PMID:27299736]
ChEMBL	Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cells	B	7.88	pKi	13.26	nM	Ki	J Med Chem (2008) 51: 1913-1924 [PMID:18298057]
ChEMBL	Displacement of [3H]DPDPE from delta opioid receptor expressed in HEK293 cells by visible spectrophotometry	B	7.88	pKi	13.26	nM	Ki	Bioorg Med Chem (2009) 17: 6671-6681 [PMID:19683449]
ChEMBL	Displacement of [3H]Naltrindole form human delta opioid receptor expressed in CHO cells	B	8.03	pKi	9.3	nM	Ki	Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293]
GtoPdb	-	-	8.1	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533]
ChEMBL	Binding affinity towards delta-opioid receptor by displacement of [3H]DADL in rat brain homogenates	B	8.47	pKi	3.4	nM	Ki	J Med Chem (1993) 36: 2842-2850 [PMID:8410999]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cells	B	8.99	pKi	1.03	nM	Ki	J Med Chem (2008) 51: 1913-1924 [PMID:18298057]
ChEMBL	Displacement of [3H]U69593 from kappa opioid receptor expressed in HEK293 cells by visible spectrophotometry	B	8.99	pKi	1.03	nM	Ki	Bioorg Med Chem (2009) 17: 6671-6681 [PMID:19683449]
GtoPdb	-	-	9.5	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
ChEMBL	Displacement of [3H]U69593 form human kappa opioid receptor expressed in CHO cells	B	9.92	pKi	0.12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293]
ChEMBL	Displacement of [3H]U69,593 from human kappa-opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting	B	10.08	pKi	0.08	nM	Ki	J Med Chem (2016) 59: 8712-8756 [PMID:27299736]
Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144]
ChEMBL	Binding affinity towards kappa opioid receptor by displacement of [3H]EKC in guinea pig cortical tissue	B	8.7	pKi	2	nM	Ki	J Med Chem (1993) 36: 2842-2850 [PMID:8410999]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Activity at human mu opioid receptor by [35S]GTPgammaS binding assay	F	9.53	pKd	0.3	nM	Kd	J Med Chem (2008) 51: 1913-1924 [PMID:18298057]
ChEMBL	Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells	B	9.04	pKi	0.91	nM	Ki	J Med Chem (2008) 51: 1913-1924 [PMID:18298057]
ChEMBL	Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cells by visible spectrophotometry	B	9.04	pKi	0.91	nM	Ki	Bioorg Med Chem (2009) 17: 6671-6681 [PMID:19683449]
ChEMBL	Displacement of [3H]DAMGO form human mu opioid receptor expressed in CHO cells	B	9.36	pKi	0.44	nM	Ki	Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293]
GtoPdb	-	-	9.5	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
ChEMBL	Displacement of [3H]DAMGO from human mu-opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting	B	9.62	pKi	0.24	nM	Ki	J Med Chem (2016) 59: 8712-8756 [PMID:27299736]
μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535]
ChEMBL	Binding affinity towards mu-opioid receptor by the displacement of [3H]Nal in rat brain homogenates	B	9.54	pKi	0.29	nM	Ki	J Med Chem (1993) 36: 2842-2850 [PMID:8410999]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]