ChEMBL ligand: CHEMBL312040 (Acscn-9624, Arc 1g2, BA-20684, Ciba 20-684ba, Etobedolum, Etonitazene, Etonitazeno, Etonitazine, IDS-NE-006, NIH 7607, NIH-7607)
δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143] δ receptor/Delta opioid receptor in Rat [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533]
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] μ receptor/Mu opioid receptor in Rat [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535]
Mu-type opioid receptor in Rhesus macaque [ChEMBL: CHEMBL5799] [UniProtKB: Q9MYW9]
κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143]
GtoPdb	-	-	6.7	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533]
ChEMBL	Opioid receptor delta 1 apparent binding constant from rat brain membranes using [3H]DADLE binding assay	B	6	pKi	>1000	nM	Ki	J Med Chem (1990) 33: 2456-2464 [PMID:2167979]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Displacement of [3H]-Diprenorphine from human mu opioid receptor expressed in HEK293-TSA cell membranes after 4 hrs by scintillation counting method	B	9.7	pKi	0.2	nM	Ki	J Med Chem (2018) 61: 1646-1663 [PMID:29400965]
GtoPdb	-	-	9.7	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
GtoPdb	Potency determined as inhibition of cAMP accumulation in a Gi-cAMP assay	-	10.52	pEC50	0.03	nM	EC50	Psychopharmacology (Berl) (2023) 240: 2573-2584 [PMID:37658878]
μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535]
GtoPdb	Binding affinity determined in radioligand displacement assay using rat brain and [3H]DAMGO as tracer	-	8.18	pKi	6.6	nM	Ki	Psychopharmacology (Berl) (2023) 240: 2573-2584 [PMID:37658878]
ChEMBL	Inhibition of [3H]DAGO binding to rat brain membrane Opioid receptor mu 1	B	9.3	pKi	0.5	nM	Ki	J Med Chem (1990) 33: 2456-2464 [PMID:2167979]
Mu-type opioid receptor in Rhesus macaque (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5799] [UniProtKB: Q9MYW9]
ChEMBL	Binding affinity to mu opioid receptor in rhesus monkey brain membrane in absence of Na+ ions	B	10.7	pKi	0.02	nM	Ki	Eur J Med Chem (2008) 43: 2307-2315 [PMID:18403056]
ChEMBL	Binding affinity to mu opioid receptor in rhesus monkey brain membrane in presence of Na+ ions	B	11	pKi	0.01	nM	Ki	Eur J Med Chem (2008) 43: 2307-2315 [PMID:18403056]
κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
GtoPdb	-	-	6.9	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]