(-)-methadone [Ligand Id: 1605] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL159659 ((6r)-methadone, D-(-)-methadone, Levadone, Levometadona, Levomethadone, Levothyl, L-methadone, L-polamivet, (-)-methadone, Methadone, l-, Polamivet, (r)-methadone, R-(-)-methadone)
  • δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143]
Created with Highcharts 10.3.3ValuesChart context menuδ receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
Created with Highcharts 10.3.3ValuesChart context menuκ receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
Created with Highcharts 10.3.3ValuesChart context menuμ receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143]
GtoPdb - - 6.9 pKi - - - NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
GtoPdb - - 6.5 pKi - - - NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
GtoPdb - - 9.2 pKi - - - NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]