Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL1774204 |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
Y1 receptor/Neuropeptide Y receptor type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4777] [GtoPdb: 305] [UniProtKB: P25929] | ||||||||
ChEMBL | Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells | B | 9.6 | pKi | 0.25 | nM | Ki | Bioorg Med Chem (2011) 19: 2859-2878 [PMID:21493077] |
GtoPdb | - | - | 9.5 | pIC50 | 0.38 | nM | IC50 | Br J Pharmacol (1998) 125: 549-555 [PMID:9806339] |
Y1 receptor in Rat [GtoPdb: 305] [UniProtKB: P21555] | ||||||||
GtoPdb | - | - | 9.7 | pIC50 | - | - | - | Br J Pharmacol (2000) 129: 37-46 [PMID:10694200] |
Y4 receptor/Neuropeptide Y receptor type 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4877] [GtoPdb: 307] [UniProtKB: P50391] | ||||||||
ChEMBL | Binding affinity to human neuropeptide Y receptor type 4 receptor expressed in CHO cells using Cy5-[K4]-hPP by flow cytometric analysis | B | 5.3 | pKi | >5000 | nM | Ki | Bioorg Med Chem (2013) 21: 6303-6322 [PMID:24074877] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]