NESS0327 [Ligand Id: 14325] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL376700 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CB1 receptor/Cannabinoid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] | ||||||||
| ChEMBL | Displacement of [3H]-CP55,940 from human CB1 receptor transfected in CHO cell membranes | B | 6.9 | pKi | 126 | nM | Ki | Eur J Med Chem (2016) 121: 194-208 [PMID:27240274] |
| ChEMBL | Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK293 cells | B | 7.74 | pKi | 18.4 | nM | Ki | J Med Chem (2008) 51: 3526-3539 [PMID:18512901] |
| ChEMBL | Displacement of [3H]SR141716 from human CB1 receptor expressed in CHO-K1 cells | B | 8.26 | pKi | 5.55 | nM | Ki | J Med Chem (2008) 51: 3526-3539 [PMID:18512901] |
| GtoPdb | Determined as displacement of [3H]SR141716 from human CB1 expressed in CHO-K1 cells | - | 8.26 | pKi | 5.55 | nM | Ki | J Med Chem (2008) 51: 3526-39 [PMID:18512901] |
| CB1 receptor/Cannabinoid receptor 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3037] [GtoPdb: 56] [UniProtKB: P47746] | ||||||||
| ChEMBL | Displacement of [3H]-CP55,940 from CB1 receptor in mouse whole brain membranes after 60 mins by liquid scintillation spectrometry | B | 8.09 | pKi | 8.18 | nM | Ki | Eur J Med Chem (2016) 121: 194-208 [PMID:27240274] |
| ChEMBL | Displacement of [3H]-CP55,940 from CB1 receptor in mouse whole brain membranes after 60 mins by liquid scintillation spectrometry | B | 8.38 | pKi | 4.2 | nM | Ki | Eur J Med Chem (2016) 121: 194-208 [PMID:27240274] |
| ChEMBL | Displacement of [3H]CP-55940 from CB1 receptor in CD1 mouse brain | B | 12.46 | pKi | 0 | nM | Ki | J Med Chem (2005) 48: 7351-7362 [PMID:16279795] |
| CB2 receptor/Cannabinoid receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] | ||||||||
| ChEMBL | Displacement of [3H]-CP55,940 from human CB2 receptor transfected in CHO cell membranes after 60 mins by liquid scintillation spectrometry | B | 7.07 | pKi | 85.2 | nM | Ki | Eur J Med Chem (2016) 121: 194-208 [PMID:27240274] |
| ChEMBL | Displacement of [3H]-CP55,940 from human CB2 receptor transfected in CHO cell membranes after 60 mins by liquid scintillation spectrometry | B | 7.25 | pKi | 55.7 | nM | Ki | Eur J Med Chem (2016) 121: 194-208 [PMID:27240274] |
| ChEMBL | Binding affinity to CB2 receptor | B | 7.68 | pKi | 21 | nM | Ki | J Med Chem (2008) 51: 2439-2446 [PMID:18363352] |
| ChEMBL | Binding affinity to CB2 receptor | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (2008) 51: 3526-3539 [PMID:18512901] |
| CB2 receptor/Cannabinoid receptor 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5373] [GtoPdb: 57] [UniProtKB: P47936] | ||||||||
| ChEMBL | Displacement of [3H]CP-55940 from CB2 receptor in CD1 mouse spleen | B | 7.68 | pKi | 21 | nM | Ki | J Med Chem (2005) 48: 7351-7362 [PMID:16279795] |
| ChEMBL | Displacement of [3H]-CP55,940 from CB2 receptor in CD1 mouse spleen homogenates after 60 mins by liquid scintillation counting method | B | 7.68 | pKi | 21 | nM | Ki | Eur J Med Chem (2016) 121: 194-208 [PMID:27240274] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
