vatiquinone [Ligand Id: 14277] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1812161 (.alpha.-tocotrienol quinone, Alpha tocotrienol quinone, Alpha-tocotrienol quinone, EPI-743, PTC-743, PTC743, (R)-Alpha-Tocotrienol Quinone, Vatiquinona, Vatiquinone)
  • 15-LOX-1 in Human [GtoPdb: 1388] [UniProtKB: P16050]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
15-LOX-1 in Human [GtoPdb: 1388] [UniProtKB: P16050]
GtoPdb - - 6.23 pIC50 590 nM IC50 US11584728B2. Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia (2023)

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]