m-chlorophenylpiperazine [Ligand Id: 142] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL478 (1-M-Chlorophenyl Piperazine Metabolite, Chlorophenylpiperazine, mCPP)
  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
  • This target only has 0 pki data point
  • 0
1 CHEMBL478_lig_chart_1 Beta-1 adrenergic receptor Human
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  • Beta-2 adrenergic receptor in Dog [ChEMBL: CHEMBL2289] [UniProtKB: P54833]
  • This target only has 0 pki data point
  • 0
2 CHEMBL478_lig_chart_2 Beta-2 adrenergic receptor Dog
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  • D1 receptor/Dopamine D1 receptor in Rat [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
  • This target only has 1 pki data point
  • 6
3 CHEMBL478_lig_chart_3 Dopamine D1 receptor Rat
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  • D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
  • This target only has 1 pki data point
  • 6
4 CHEMBL478_lig_chart_4 Dopamine D2 receptor Rat
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
  • 6.84
5 CHEMBL478_lig_chart_5 Serotonin 1a (5-HT1a) receptor HumanRat
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  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
  • 7.74
6 CHEMBL478_lig_chart_6 Serotonin 1b (5-HT1b) receptor Rat
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  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
  • 5-HT2A receptor in Rat [GtoPdb: 6] [UniProtKB: P14842]
  • 6.4
7 CHEMBL478_lig_chart_7 Serotonin 2a (5-HT2a) receptor HumanRat
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  • 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
  • 5-HT2B receptor in Rat [GtoPdb: 7] [UniProtKB: P30994]
  • 7.6
8 CHEMBL478_lig_chart_8 Serotonin 2b (5-HT2b) receptor HumanRat
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  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
  • 5-HT2C receptor in Rat [GtoPdb: 8] [UniProtKB: P08909]
  • 7.2
9 CHEMBL478_lig_chart_9 Serotonin 2c (5-HT2c) receptor HumanRat
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10 CHEMBL478_lig_chart_10 Serotonin 3 (5-HT3) receptor Human
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  • 5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Mouse [ChEMBL: CHEMBL3597] [GtoPdb: 10] [UniProtKB: P30966]
  • 5.06
11 CHEMBL478_lig_chart_11 Serotonin 5a (5-HT5a) receptor Mouse
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  • 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
  • 5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388]
  • 5.6
12 CHEMBL478_lig_chart_12 Serotonin 6 (5-HT6) receptor HumanRat
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  • 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
  • 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305]
  • 6.53
13 CHEMBL478_lig_chart_13 Serotonin 7 (5-HT7) receptor HumanRat
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  • SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
  • This target only has 1 pki data point
  • 6.57
14 CHEMBL478_lig_chart_14 Serotonin transporter Human
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  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
  • This target only has 1 pki data point
  • 5.21
15 CHEMBL478_lig_chart_15 Sigma opioid receptor Human
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  • 5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221]
  • This target only has 1 pki data point
  • 6.7
16 CHEMBL478_lig_chart_16 5-HT1D receptor Human
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  • 5-ht1e receptor in Human [GtoPdb: 4] [UniProtKB: P28566]
  • This target only has 1 pki data point
  • 5.4
17 CHEMBL478_lig_chart_17 5-ht1e receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
ChEMBL Binding affinity for Beta-1 adrenergic receptor by displacing [3H]dihydroalprenolol, in partially purified membrane fractions from canine ventricular muscle in the presence of 1 uM zinterol B 5.7 pIC50 2000 nM IC50 J. Med. Chem. (1992) 35: 743-750 [PMID:1347318]
Beta-2 adrenergic receptor in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2289] [UniProtKB: P54833]
ChEMBL Binding affinity towards Beta-2 adrenergic receptor by displacing [3H]dihydroalprenolol, in partially purified membrane fractions from canine lung tissue in the presence of 0.1 uM metoprolol B 4.74 pIC50 18000 nM IC50 J. Med. Chem. (1992) 35: 743-750 [PMID:1347318]
D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
ChEMBL Binding affinity at rat Dopamine receptor D1 by [3H]SCH-23390 displacement. B 6 pKi >1000 nM Ki J. Med. Chem. (1989) 32: 1052-1056 [PMID:2565400]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL Binding affinity against rat Dopamine receptor D2. B 6 pKi >1000 nM Ki J. Med. Chem. (1989) 32: 1052-1056 [PMID:2565400]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Binding affinity to 5HT1A receptor B 7 pKd 100 nM Kd J. Med. Chem. (2009) 52: 6107-6125 [PMID:19754201]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL Evaluated for the binding affinity to hippocampus striatal membranes at 5-hydroxytryptamine 1A receptor binding site by using [3H]-8-OH- DPAT as a radioligand. B 5.62 pKi 2400 nM Ki J. Med. Chem. (1987) 30: 1-12 [PMID:3543362]
ChEMBL Displacement of radioligand [3H]2-(di-N-propylamino)-8-hydroxytetralin from 5-hydroxytryptamine 1A receptor in rat frontal cortex homogenate (experiment 1) B 6.7 pKi 200 nM Ki J. Med. Chem. (1993) 36: 2751-2760 [PMID:8410989]
ChEMBL Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement B 6.84 pKi 144.54 nM Ki J. Med. Chem. (1996) 39: 126-134 [PMID:8568799]
ChEMBL Displacement of radioligand [3H]2-(di-N-propylamino)-8-hydroxytetralin from 5-hydroxytryptamine 1A receptor in rat frontal cortex homogenate (experiment 2) B 6.84 pKi 143 nM Ki J. Med. Chem. (1993) 36: 2751-2760 [PMID:8410989]
ChEMBL In vitro ability to displace [3H]8-hydroxy-2-(di-n-propylamino) tetralin binding from 5-hydroxytryptamine 1A receptor site in rat brain hippocampus B 6.84 pKi 143 nM Ki J. Med. Chem. (1992) 35: 2369-2374 [PMID:1535661]
ChEMBL Binding affinity towards rat 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT radioligand. B 6.89 pKi 130 nM Ki J. Med. Chem. (1996) 39: 4439-4450 [PMID:8893838]
ChEMBL Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain B 6.89 pKi 130 nM Ki J. Med. Chem. (1988) 31: 1968-1971 [PMID:3172131]
ChEMBL Binding affinity at rat 5-hydroxytryptamine 1A receptor by [3H]WB-4101 displacement. B 7.64 pKi 23 nM Ki J. Med. Chem. (1989) 32: 1052-1056 [PMID:2565400]
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
ChEMBL Binding affinity (Ki) to rat cortical membranes at 5-HT1B binding site by using [125 I] ICYP as a radioligand. B 7.12 pKi 75 nM Ki J. Med. Chem. (1987) 30: 1-12 [PMID:3543362]
ChEMBL Binding affinity at rat 5-hydroxytryptamine 1B receptor by [3H]5-HT displacement. B 8.36 pKi 4.4 nM Ki J. Med. Chem. (1989) 32: 1052-1056 [PMID:2565400]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL Binding affinity to 5HT2A (unknown origin) B 6.56 pKi 273 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 914-920 [PMID:26748694]
ChEMBL Affinity for human 5-hydroxytryptamine 2A receptor expressed in mammalian cell line B 7.27 pKi 54 nM Ki Bioorg. Med. Chem. Lett. (2004) 14: 2367-2370 [PMID:15081042]
ChEMBL Displacement of [125I]DOI from human 5HT2A B 7.27 pKi 54 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 677-680 [PMID:16257207]
ChEMBL Displacement of [125I]DOI from human recombinant 5HT2A expressed in HEK293E cells B 7.32 pKi 48 nM Ki J. Med. Chem. (2007) 50: 1365-1379 [PMID:17315987]
ChEMBL Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in HEK293E cells B 7.32 pKi 48 nM Ki Bioorg. Med. Chem. Lett. (2010) 20: 1128-1133 [PMID:20022752]
GtoPdb - - 7.5 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733];
Biochem Pharmacol (1996) 51: 71-6 [PMID:8534270];
Naunyn Schmiedebergs Arch Pharmacol (1999) 359: 1-6 [PMID:9933142]
ChEMBL Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay F 6.54 pEC50 290 nM EC50 Bioorg. Med. Chem. Lett. (2010) 20: 1128-1133 [PMID:20022752]
ChEMBL Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay F 6.54 pEC50 290 nM EC50 J. Med. Chem. (2007) 50: 1365-1379 [PMID:17315987]
ChEMBL Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay F 6.78 pEC50 167 nM EC50 Bioorg. Med. Chem. Lett. (2009) 19: 5791-5795 [PMID:19716297]
ChEMBL Binding to human 5HT2A receptor expressed in CHO cells B 7.12 pEC50 75 nM EC50 Bioorg. Med. Chem. Lett. (2006) 16: 677-680 [PMID:16257207]
ChEMBL Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader F 7.12 pEC50 75 nM EC50 Bioorg. Med. Chem. Lett. (2004) 14: 2367-2370 [PMID:15081042]
ChEMBL Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation F 7.2 pEC50 63.1 nM EC50 J. Med. Chem. (2008) 51: 305-313 [PMID:18095642]
ChEMBL Agonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay F 8.14 pEC50 7.2 nM EC50 Eur. J. Med. Chem. (2013) 63: 558-569 [PMID:23537943]
5-HT2A receptor in Rat [GtoPdb: 6] [UniProtKB: P14842]
GtoPdb - - 6.4 pKi - - - Circulation (2000) 102: 2836-41 [PMID:11104741]
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
ChEMBL Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line B 7.49 pKi 32 nM Ki Bioorg. Med. Chem. Lett. (2004) 14: 2367-2370 [PMID:15081042]
ChEMBL Displacement of [3H]5-HT from human 5HT2B B 7.49 pKi 32 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 677-680 [PMID:16257207]
ChEMBL Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells B 7.62 pKi 24 nM Ki J. Med. Chem. (2007) 50: 1365-1379 [PMID:17315987]
ChEMBL Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells B 7.62 pKi 24 nM Ki Bioorg. Med. Chem. Lett. (2010) 20: 1128-1133 [PMID:20022752]
GtoPdb - - 8.5 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733];
Circulation (2000) 102: 2836-41 [PMID:11104741];
Naunyn Schmiedebergs Arch Pharmacol (1999) 359: 1-6 [PMID:9933142];
Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 17-24 [PMID:9459568];
Br J Pharmacol (2003) 140: 277-84 [PMID:12970106]
ChEMBL Binding to human 5HT2B receptor expressed in CHO cells B 6 pEC50 >1000 nM EC50 Bioorg. Med. Chem. Lett. (2006) 16: 677-680 [PMID:16257207]
ChEMBL Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader F 6 pEC50 >1000 nM EC50 Bioorg. Med. Chem. Lett. (2004) 14: 2367-2370 [PMID:15081042]
ChEMBL Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay F 6.54 pEC50 287 nM EC50 Bioorg. Med. Chem. Lett. (2010) 20: 1128-1133 [PMID:20022752]
ChEMBL Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay F 6.54 pEC50 287 nM EC50 J. Med. Chem. (2007) 50: 1365-1379 [PMID:17315987]
ChEMBL Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay F 6.9 pEC50 125 nM EC50 Bioorg. Med. Chem. Lett. (2009) 19: 5791-5795 [PMID:19716297]
ChEMBL Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay F 6.9 pEC50 125 nM EC50 Bioorg. Med. Chem. Lett. (2009) 19: 4999-5003 [PMID:19646865]
ChEMBL Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation F 7.4 pEC50 39.81 nM EC50 J. Med. Chem. (2008) 51: 305-313 [PMID:18095642]
5-HT2B receptor in Rat [GtoPdb: 7] [UniProtKB: P30994]
GtoPdb - - 7.6 pKi - - - Mol Pharmacol (1993) 43: 419-26 [PMID:8450835]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL Binding affinity to 5HT2C (unknown origin) B 7.56 pKi 27.7 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 914-920 [PMID:26748694]
ChEMBL Displacement of [125I]DOI from human recombinant 5HT2C expressed in HEK293E cells B 7.77 pKi 17 nM Ki J. Med. Chem. (2007) 50: 1365-1379 [PMID:17315987]
ChEMBL Displacement of [125I]DOI from human recombinant 5HT2C receptor expressed in HEK293E cells B 7.77 pKi 17 nM Ki Bioorg. Med. Chem. Lett. (2010) 20: 1128-1133 [PMID:20022752]
ChEMBL Affinity for human 5-hydroxytryptamine 2C receptor expressed in mammalian cell line B 8.05 pKi 9 nM Ki Bioorg. Med. Chem. Lett. (2004) 14: 2367-2370 [PMID:15081042]
ChEMBL Displacement of [3H]5-HT from human 5HT2C B 8.05 pKi 9 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 677-680 [PMID:16257207]
ChEMBL Displacement of [125I]DOI from recombinant human 5-HT2C receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting B 8.1 pKi 7.94 nM Ki Bioorg Med Chem Lett (2016) 26: 5877-5882 [PMID:27864071]
GtoPdb - - 8.5 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733];
Naunyn Schmiedebergs Arch Pharmacol (1999) 359: 1-6 [PMID:9933142];
Br J Pharmacol (2003) 140: 277-84 [PMID:12970106];
J Neurochem (1999) 72: 2127-34 [PMID:10217294];
Synapse (2000) 35: 144-150 [PMID:10611640];
Eur J Pharmacol (2004) 483: 37-43 [PMID:14709324]
ChEMBL Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay F 6.77 pEC50 170 nM EC50 Bioorg. Med. Chem. Lett. (2009) 19: 4999-5003 [PMID:19646865]
ChEMBL Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay F 6.77 pEC50 170 nM EC50 Bioorg. Med. Chem. Lett. (2009) 19: 5791-5795 [PMID:19716297]
ChEMBL Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader F 7.59 pEC50 26 nM EC50 Bioorg. Med. Chem. Lett. (2004) 14: 2367-2370 [PMID:15081042]
ChEMBL Binding to human 5HT2C receptor expressed in CHO cells B 7.59 pEC50 26 nM EC50 Bioorg. Med. Chem. Lett. (2006) 16: 677-680 [PMID:16257207]
ChEMBL Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay F 7.82 pEC50 15 nM EC50 J. Med. Chem. (2007) 50: 1365-1379 [PMID:17315987]
ChEMBL Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay F 7.82 pEC50 15 nM EC50 Bioorg. Med. Chem. Lett. (2010) 20: 1128-1133 [PMID:20022752]
ChEMBL Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay B 7.82 pEC50 15 nM EC50 J Med Chem (2017) 60: 6166-6190 [PMID:28635286]
ChEMBL Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting B 7.9 pEC50 12.59 nM EC50 Bioorg Med Chem Lett (2016) 26: 5877-5882 [PMID:27864071]
ChEMBL Agonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay F 8.09 pEC50 8.1 nM EC50 Eur. J. Med. Chem. (2013) 63: 558-569 [PMID:23537943]
ChEMBL Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation F 8.1 pEC50 7.94 nM EC50 J. Med. Chem. (2008) 51: 305-313 [PMID:18095642]
5-HT2C receptor in Rat [GtoPdb: 8] [UniProtKB: P08909]
GtoPdb - - 7.2 pKi - - - Circulation (2000) 102: 2836-41 [PMID:11104741]
5-HT3E/5-HT3B/5-HT3A/5-HT3D/5-HT3C/Serotonin 3 (5-HT3) receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094132] [GtoPdb: 377374373376375] [UniProtKB: A5X5Y0O95264P46098Q70Z44Q8WXA8]
ChEMBL Compound was tested for the inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor expressed in NG 108-15 cells B 7.21 pKi 62 nM Ki J. Med. Chem. (1996) 39: 4017-4026 [PMID:8831767]
5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3597] [GtoPdb: 10] [UniProtKB: P30966]
ChEMBL Binding affinity towards murine 5-hydroxytryptamine 5A receptor B 5.06 pKi 8700 nM Ki J. Med. Chem. (2003) 46: 2795-2812 [PMID:12825922]
ChEMBL Binding affinity towards mouse 5-hydroxytryptamine 5A receptor was evaluated using [3H]LSD as radioligand B 5.06 pKi 8700 nM Ki J. Med. Chem. (2003) 46: 2795-2812 [PMID:12825922]
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL Binding affinity towards human 5-hydroxytryptamine 6 receptor was evaluated using [125I]-2-iodo LSD as radioligand B 5.64 pKi 2300 nM Ki J. Med. Chem. (2003) 46: 2795-2812 [PMID:12825922]
5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388]
GtoPdb - - 5.6 pKi - - - Mol Pharmacol (1993) 43: 320-7 [PMID:7680751]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
ChEMBL Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor B 6.52 pKi 304 nM Ki J. Med. Chem. (2003) 46: 2795-2812 [PMID:12825922]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305]
ChEMBL Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells B 6.45 pKi 352 nM Ki J. Med. Chem. (2012) 55: 6375-6380 [PMID:22738316]
GtoPdb - - 6.6 pKi - - - J Biol Chem (1993) 268: 18200-4 [PMID:8394362]
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
ChEMBL Binding affinity to SERT (unknown origin) B 6.57 pKi 271 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 914-920 [PMID:26748694]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL Binding affinity towards sigma receptor in guinea pig brain membranes using [3H]DTG as radioligand B 5.21 pKi 6150 nM Ki J. Med. Chem. (1991) 34: 3360-3365 [PMID:1662725]
5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221]
GtoPdb - - 6.7 pKi - - - Mol Pharmacol (1991) 40: 143-8 [PMID:1652050]
5-ht1e receptor in Human [GtoPdb: 4] [UniProtKB: P28566]
GtoPdb - - 5.4 pKi - - - Eur J Pharmacol (2004) 484: 127-39 [PMID:14744596]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]