L-serine-O-phosphate [Ligand Id: 1411] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL284377 (Dexfosfoserine, Dl-o-phosphorylserine, Dl-phosphoserine, Energoserina, Fosforina, GNF-PF-1028, L-o-phosphoserine, L-o-serine phosphate, L-phosphoserine, NSC-760136, NSC-90791, O-phosphoryl-l-serine, O-phosphoserine, l-, Phosphoserine, dl-, Serine phosphate, Seriphos, Serophen) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu4 receptor/Metabotropic glutamate receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2736] [GtoPdb: 292] [UniProtKB: Q14833] | ||||||||
| ChEMBL | Concentration for half maximal activation of metabotropic glutamate mGluR4a in human | B | 5.89 | pEC50 | 1300 | nM | EC50 | J Med Chem (1995) 38: 1417-1426 [PMID:7738999] |
| GtoPdb | - | - | 5.9 | pEC50 | 1420 | nM | EC50 | Brain Res Mol Brain Res (1998) 53: 88-97 [PMID:9473604] |
| ChEMBL | Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay | B | 6 | pEC50 | 1000 | nM | EC50 | Bioorg Med Chem Lett (2000) 10: 1447-1450 [PMID:10888329] |
| mGlu4 receptor/Metabotropic glutamate receptor 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2787] [GtoPdb: 292] [UniProtKB: P31423] | ||||||||
| GtoPdb | - | - | 6.2 | pIC50 | - | - | - |
J Neurosci (1993) 13: 1372-8 [PMID:8463825]; Neuropharmacology (1997) 36: 21-30 [PMID:9144638]; Br J Pharmacol (1995) 116: 3279-87 [PMID:8719808]; J Biol Chem (1999) 274: 10008-13 [PMID:10187777]; Neuroreport (1993) 4: 1099-101 [PMID:8106006] |
| ChEMBL | Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Active | F | 4 | pEC50 | <100000 | nM | EC50 | J Med Chem (2005) 48: 2534-2547 [PMID:15801843] |
| ChEMBL | Concentration for half maximal activation of metabotropic glutamate mGluR4a in rat | B | 5.4 | pEC50 | 4000 | nM | EC50 | J Med Chem (1995) 38: 1417-1426 [PMID:7738999] |
| mGlu6 receptor in Human [GtoPdb: 294] [UniProtKB: O15303] | ||||||||
| GtoPdb | - | - | 6.4 | pEC50 | - | - | - | Neuropharmacology (1997) 36: 145-52 [PMID:9144651] |
| mGlu6 receptor/Metabotropic glutamate receptor 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3842] [GtoPdb: 294] [UniProtKB: P35349] | ||||||||
| ChEMBL | Concentration for half maximal activation of metabotropic glutamate mGluR6 in rat | B | 5.57 | pEC50 | 2700 | nM | EC50 | J Med Chem (1995) 38: 1417-1426 [PMID:7738999] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | F | 5.97 | pEC50 | 1080 | nM | EC50 | Proc Natl Acad Sci U S A (2008) 105: 9059-9064 [PMID:18579783] |
| ChEMBL | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | F | 5.97 | pEC50 | >1065 | nM | EC50 | Proc Natl Acad Sci U S A (2008) 105: 9059-9064 [PMID:18579783] |
| mGlu7 receptor in Human [GtoPdb: 295] [UniProtKB: Q14831] | ||||||||
| GtoPdb | - | - | 4.4 | pKi | - | - | - | Naunyn Schmiedebergs Arch Pharmacol (2000) 362: 546-54 [PMID:11138847] |
| GtoPdb | - | - | 4.5 | pEC50 | 31000 | nM | EC50 | Brain Res Mol Brain Res (1998) 53: 88-97 [PMID:9473604] |
| mGlu8 receptor in Human [GtoPdb: 296] [UniProtKB: O00222] | ||||||||
| GtoPdb | - | - | 7.2 | pIC50 | - | - | - |
Brain Res Mol Brain Res (1998) 53: 88-97 [PMID:9473604]; Brain Res Mol Brain Res (1999) 67: 201-10 [PMID:10216218] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
