UCB-9260 [Ligand Id: 13912] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4743779 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TNF-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1825] [UniProtKB: P01375] | ||||||||
| ChEMBL | Binding affinity to human TNF measured after 2 hrs by surface plasmon resonance | B | 7.89 | pKd | 13 | nM | Kd | J Med Chem (2020) 63: 15494-15507 [PMID:33226222] |
| ChEMBL | Inhibition of human TNF-alpha assessed as dissociation constant incubated for 5 hrs by SPR analysis | B | 7.89 | pKd | 13 | nM | Kd | Bioorg Med Chem Lett (2021) 48: 128229-128229 [PMID:34214508] |
| ChEMBL | Binding affinity to human TNF-alpha assessed as dissociation constant by SPR assay | B | 7.89 | pKd | 13 | nM | Kd | RSC Med Chem (2023) 14: 22-46 [PMID:36760737] |
| ChEMBL | Inhibition of exogenous human TNFalpha in HEK-Blue-CD40L cells assessed as reduction in TNF-alpha-induced NFkappaB activation incubated for 18 hrs by quanti-blue based SEAP assay | B | 6.69 | pIC50 | 202 | nM | IC50 | J Med Chem (2020) 63: 15050-15071 [PMID:33261314] |
| TNF-alpha in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4984] [UniProtKB: P06804] | ||||||||
| ChEMBL | Inhibition of mouse TNF-alpha in mouse L929 cells incubated for 18 hrs by CellTitreGlo assay | B | 6.9 | pIC50 | 125 | nM | IC50 | Bioorg Med Chem Lett (2021) 48: 128229-128229 [PMID:34214508] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
