ChEMBL ligand: CHEMBL5398215
coactivator associated arginine methyltransferase 1/Histone-arginine methyltransferase CARM1 in Human [ChEMBL: CHEMBL5406] [GtoPdb: 1255] [UniProtKB: Q86X55] There should be some charts here, you may need to enable JavaScript!
protein arginine methyltransferase 5 /PRMT5/MEP50 complex in Human [ChEMBL: CHEMBL3137261] [GtoPdb: 1256] [UniProtKB: O14744, Q9BQA1] There should be some charts here, you may need to enable JavaScript!
protein arginine methyltransferase 1 /Protein arginine N-methyltransferase 1 in Human [ChEMBL: CHEMBL5524] [GtoPdb: 1252] [UniProtKB: Q99873] There should be some charts here, you may need to enable JavaScript!
protein arginine methyltransferase 3/Protein arginine N-methyltransferase 3 in Human [ChEMBL: CHEMBL5891] [GtoPdb: 1254] [UniProtKB: O60678] There should be some charts here, you may need to enable JavaScript!
protein arginine methyltransferase 5 /Protein arginine N-methyltransferase 5 in Human [ChEMBL: CHEMBL1795116] [GtoPdb: 1256] [UniProtKB: O14744] There should be some charts here, you may need to enable JavaScript!
protein arginine methyltransferase 6/Protein arginine N-methyltransferase 6 in Human [ChEMBL: CHEMBL1275221] [GtoPdb: 1257] [UniProtKB: Q96LA8] There should be some charts here, you may need to enable JavaScript!
protein arginine methyltransferase 7 /Protein arginine N-methyltransferase 7 in Human [ChEMBL: CHEMBL3562175] [GtoPdb: 1258] [UniProtKB: Q9NVM4] There should be some charts here, you may need to enable JavaScript!
protein arginine methyltransferase 8/Protein arginine N-methyltransferase 8 in Human [ChEMBL: CHEMBL3108648] [GtoPdb: 1259] [UniProtKB: Q9NR22] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
coactivator associated arginine methyltransferase 1/Histone-arginine methyltransferase CARM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5406] [GtoPdb: 1255] [UniProtKB: Q86X55]
ChEMBL	Inhibition of PRMT4 (unknown origin)	B	5	pIC50	>10000	nM	IC50	J Med Chem (2025) 68: 108-134 [PMID:39722476]
protein arginine methyltransferase 5 /PRMT5/MEP50 complex in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3137261] [GtoPdb: 1256] [UniProtKB: O14744, Q9BQA1]
ChEMBL	Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by SPR analysis	B	6.98	pKd	104	nM	Kd	J Med Chem (2025) 68: 108-134 [PMID:39722476]
GtoPdb	-	-	7.68	pIC50	20.7	nM	IC50	J Med Chem (2025) 68: 108-134 [PMID:39722476]
ChEMBL	Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [3H]-SAM as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by multimode plate reader analysis	B	7.68	pIC50	20.7	nM	IC50	J Med Chem (2025) 68: 108-134 [PMID:39722476]
protein arginine methyltransferase 1 /Protein arginine N-methyltransferase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5524] [GtoPdb: 1252] [UniProtKB: Q99873]
ChEMBL	Inhibition of PRMT1 (unknown origin)	B	5	pIC50	>10000	nM	IC50	J Med Chem (2025) 68: 108-134 [PMID:39722476]
protein arginine methyltransferase 3/Protein arginine N-methyltransferase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5891] [GtoPdb: 1254] [UniProtKB: O60678]
ChEMBL	Inhibition of PRMT3 (unknown origin)	B	5	pIC50	>10000	nM	IC50	J Med Chem (2025) 68: 108-134 [PMID:39722476]
protein arginine methyltransferase 5 /Protein arginine N-methyltransferase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795116] [GtoPdb: 1256] [UniProtKB: O14744]
ChEMBL	Inhibition of PRMT5 (unknown origin) using H4(1-21)S1ac as substrate preincubated for 15 mins followed by substrate addition and measured for 60 mins by scintillation counting analysis	B	7.3	pIC50	49.7	nM	IC50	J Med Chem (2023) 66: 8407-8427 [PMID:37366223]
GtoPdb	-	-	7.68	pIC50	20.7	nM	IC50	J Med Chem (2025) 68: 108-134 [PMID:39722476]
protein arginine methyltransferase 6/Protein arginine N-methyltransferase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1275221] [GtoPdb: 1257] [UniProtKB: Q96LA8]
ChEMBL	Inhibition of PRMT6 (unknown origin)	B	5	pIC50	>10000	nM	IC50	J Med Chem (2025) 68: 108-134 [PMID:39722476]
protein arginine methyltransferase 7 /Protein arginine N-methyltransferase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3562175] [GtoPdb: 1258] [UniProtKB: Q9NVM4]
ChEMBL	Inhibition of PRMT7 (unknown origin)	B	5	pIC50	>10000	nM	IC50	J Med Chem (2025) 68: 108-134 [PMID:39722476]
protein arginine methyltransferase 8/Protein arginine N-methyltransferase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3108648] [GtoPdb: 1259] [UniProtKB: Q9NR22]
ChEMBL	Inhibition of PRMT8 (unknown origin)	B	5	pIC50	>10000	nM	IC50	J Med Chem (2025) 68: 108-134 [PMID:39722476]

ChEMBL data shown on this page come from version 37:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]