salvianolic acid B [Ligand Id: 13515] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1615434
  • lysine demethylase 1A/Lysine-specific histone demethylase 1 in Human [ChEMBL: CHEMBL6136] [GtoPdb: 2669] [UniProtKB: O60341]
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  • P2Y12 receptor/Purinergic receptor P2Y12 in Human [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244]
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  • platelet derived growth factor receptor beta in Human [GtoPdb: 1804] [UniProtKB: P09619]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
lysine demethylase 1A/Lysine-specific histone demethylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6136] [GtoPdb: 2669] [UniProtKB: O60341]
ChEMBL Inhibition of LSD1 (unknown origin) by Spectra Max Paradigm Microplate Reader analysis B 6.96 pIC50 110 nM IC50 Eur J Med Chem (2021) 214: 113254-113254 [PMID:33581557]
ChEMBL Inhibition of LSD1 (unknown origin) by microplate reader method B 6.96 pIC50 110 nM IC50 Eur J Med Chem (2022) 240: 114564-114564 [PMID:35820351]
GtoPdb - - 6.96 pIC50 110 nM IC50 Talanta (2020) 206: 120195 [PMID:31514831]
P2Y12 receptor/Purinergic receptor P2Y12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244]
ChEMBL Displacement of [3H]2MeSADP from human P2Y12 expressed in U2OS cell membranes incubated for 60 mins by scintillation counting method B 4.44 pKi 36400 nM Ki Eur J Med Chem (2022) 227: 113924-113924 [PMID:34731765]
platelet derived growth factor receptor beta in Human [GtoPdb: 1804] [UniProtKB: P09619]
GtoPdb Binding affinity determined by surface plasmon resonance analysis - 5.21 pKd 6150 nM Kd Int Immunopharmacol (2023) 122: 110550 [PMID:37451016]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]