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ChEMBL ligand: CHEMBL1615434 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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lysine demethylase 1A/Lysine-specific histone demethylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6136] [GtoPdb: 2669] [UniProtKB: O60341] | ||||||||
ChEMBL | Inhibition of LSD1 (unknown origin) by Spectra Max Paradigm Microplate Reader analysis | B | 6.96 | pIC50 | 110 | nM | IC50 | Eur J Med Chem (2021) 214: 113254-113254 [PMID:33581557] |
ChEMBL | Inhibition of LSD1 (unknown origin) by microplate reader method | B | 6.96 | pIC50 | 110 | nM | IC50 | Eur J Med Chem (2022) 240: 114564-114564 [PMID:35820351] |
GtoPdb | - | - | 6.96 | pIC50 | 110 | nM | IC50 | Talanta (2020) 206: 120195 [PMID:31514831] |
P2Y12 receptor/Purinergic receptor P2Y12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244] | ||||||||
ChEMBL | Displacement of [3H]2MeSADP from human P2Y12 expressed in U2OS cell membranes incubated for 60 mins by scintillation counting method | B | 4.44 | pKi | 36400 | nM | Ki | Eur J Med Chem (2022) 227: 113924-113924 [PMID:34731765] |
platelet derived growth factor receptor beta in Human [GtoPdb: 1804] [UniProtKB: P09619] | ||||||||
GtoPdb | Binding affinity determined by surface plasmon resonance analysis | - | 5.21 | pKd | 6150 | nM | Kd | Int Immunopharmacol (2023) 122: 110550 [PMID:37451016] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]