WN1703 [Ligand Id: 13463] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL4217468
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  • xanthine dehydrogenase in Bovine [GtoPdb: 2646]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Xanthine dehydrogenase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3649] [UniProtKB: P80457]
ChEMBL Inhibition of bovine milk xanthine oxidoreductase pre-incubated for 3 mins followed xanthine substrate addition and measured every 1 mins for 10 mins by spectrophotometry B 8.24 pIC50 5.7 nM IC50 Eur J Med Chem (2017) 140: 20-30 [PMID:28918097]
xanthine dehydrogenase in Bovine [GtoPdb: 2646]
GtoPdb Inhibition of XHD in cow's milk - 8.24 pIC50 5.7 nM IC50 Eur J Med Chem (2017) 140: 20-30 [PMID:28918097]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]