silevertinib [Ligand Id: 13371] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| GtoPdb | Inhibition of WT hEGFR phosphorylation | - | 7.6 | pIC50 | <25 | nM | IC50 | WO2021030711A1. Alkynyl quinazoline compounds (2021) |
| GtoPdb | Inhibition of phosphorylation of EGFR with mutantions A289V and G598V | - | 8 | pIC50 | <10 | nM | IC50 | WO2021030711A1. Alkynyl quinazoline compounds (2021) |
| GtoPdb | Inhibition of hEGFRV3 (constitutively activated mutant) phosphorylation | - | 8 | pIC50 | 10 | nM | IC50 | WO2021030711A1. Alkynyl quinazoline compounds (2021) |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
