RY764 [Ligand Id: 1337] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL364346 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| MC2 receptor/Melanocortin receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1965] [GtoPdb: 283] [UniProtKB: Q01718] | ||||||||
| ChEMBL | Inhibition concentration (binding affinity) against human melanocortin receptor 2 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| MC3 receptor/Melanocortin receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4644] [GtoPdb: 284] [UniProtKB: P41968] | ||||||||
| ChEMBL | Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells | B | 6.03 | pIC50 | 942 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| MC4 receptor/Melanocortin receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL259] [GtoPdb: 285] [UniProtKB: P32245] | ||||||||
| ChEMBL | Inhibition concentration (binding affinity) against human melanocortin receptor 4 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells | B | 5.1 | pIC50 | 8000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| ChEMBL | Inhibition concentration (binding affinity) against dog melanocortin receptor 4 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells | B | 5.15 | pIC50 | 7000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| ChEMBL | Inhibition concentration (binding affinity) against human melanocortin receptor 4 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells | B | 8.1 | pIC50 | 8 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| GtoPdb | - | - | 8.1 | pIC50 | - | - | - | Bioorg Med Chem Lett (2005) 15: 3501-5 [PMID:15982875] |
| ChEMBL | Effective concentration (binding affinity) exhibited against human melanocortin receptor 4 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells) | F | 4.96 | pEC50 | 11000 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| ChEMBL | Concentration of compound at 50% maximum cAMP accumulation in human melanocortin receptor (hMC4R) | F | 4.96 | pEC50 | 11000 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| ChEMBL | Concentration of compound at 50% maximum cAMP accumulation in dog melanocortin receptor (dMC4R) | F | 4.96 | pEC50 | 11000 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| ChEMBL | Effective concentration (binding affinity) exhibited against human melanocortin receptor 4 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells) | F | 7.96 | pEC50 | 11 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| MC4 receptor/Melanocortin receptor 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3719] [GtoPdb: 285] [UniProtKB: P56450] | ||||||||
| ChEMBL | Inhibition concentration (binding affinity) against mouse melanocortin receptor 4 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells | B | 5.52 | pIC50 | 3000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| ChEMBL | Concentration of compound at 50% maximum cAMP accumulation in mouse melanocortin receptor (mMC4R) | F | 5.22 | pEC50 | 6000 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| MC4 receptor/Melanocortin receptor 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2700] [GtoPdb: 285] [UniProtKB: P70596] | ||||||||
| ChEMBL | Inhibition concentration (binding affinity) against rat melanocortin receptor 4 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells | B | 5.52 | pIC50 | 3000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| ChEMBL | Concentration of compound at 50% maximum cAMP accumulation in rat melanocortin receptor (rMC4R) | F | 5.3 | pEC50 | 5000 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| MC5 receptor/Melanocortin receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4608] [GtoPdb: 286] [UniProtKB: P33032] | ||||||||
| ChEMBL | Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells | B | 6.02 | pIC50 | 945 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| ChEMBL | Effective concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells) | F | 6.07 | pEC50 | 850 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
