famlasertib [Ligand Id: 13267] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL5413518 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2708] [GtoPdb: 2071] [UniProtKB: Q16584] | ||||||||
| ChEMBL | Inhibition of MLK3 (unknown origin) | B | 7.63 | pIC50 | 23.7 | nM | IC50 | Eur J Med Chem (2023) 257: 115511-115511 [PMID:37247505] |
| ChEMBL | Inhibition of MLK3 (unknown origin) by cell-free radiolabeled ATP assay | B | 7.63 | pIC50 | 23.7 | nM | IC50 | Bioorg Med Chem Lett (2024) 101: 129652-129652 [PMID:38346577] |
| mitogen-activated protein kinase kinase kinase 9/Mitogen-activated protein kinase kinase kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2872] [GtoPdb: 2084] [UniProtKB: P80192] | ||||||||
| ChEMBL | Inhibition of MLK1 (unknown origin) | B | 7.35 | pIC50 | 44.7 | nM | IC50 | Eur J Med Chem (2023) 257: 115511-115511 [PMID:37247505] |
| mitogen-activated protein kinase kinase kinase kinase 4 in Human [GtoPdb: 2088] [UniProtKB: O95819] | ||||||||
| GtoPdb | Inhibition of HGK activity in cell-free radiolabeled ATP assay | - | 9.52 | pIC50 | 0.3 | nM | IC50 | Cell Chem Biol (2019) 26: 1703-1715.e37 [PMID:31676236] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
