ChEMBL ligand: CHEMBL178707 (T-226296)
MCH1 receptor/Melanin-concentrating hormone receptor 1 in Human [ChEMBL: CHEMBL344] [GtoPdb: 280] [UniProtKB: Q99705] MCH1 receptor/Melanin-concentrating hormone receptor 1 in Rat [ChEMBL: CHEMBL1075228] [GtoPdb: 280] [UniProtKB: P97639] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
MCH1 receptor/Melanin-concentrating hormone receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL344] [GtoPdb: 280] [UniProtKB: Q99705]
ChEMBL	Displacement of [125I][Phe13, Tyr19]MCH from human recombinant MCHR1 expressed in CHO cells	B	7.42	pKi	38	nM	Ki	Bioorg Med Chem Lett (2007) 17: 3754-3759 [PMID:17448659]
ChEMBL	Displacement of [125I]MCH from human Melanin-concentrating hormone 1 (MCH1) receptor modified for optimal expression in HEK293 cells	B	8.26	pKi	5.5	nM	Ki	Bioorg Med Chem Lett (2005) 15: 999-1004 [PMID:15686900]
ChEMBL	Concentration required to inhibit 50% of melanin-concentrating hormone induced [Ca2+] flux in IMR-32 cells measured by using a fluorometric imaging plate reader	F	6.06	pIC50	872	nM	IC50	Bioorg Med Chem Lett (2004) 14: 4879-4882 [PMID:15341943]
ChEMBL	Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes	B	7.07	pIC50	85	nM	IC50	Bioorg Med Chem Lett (2004) 14: 4879-4882 [PMID:15341943]
ChEMBL	Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH-induced GTPgammaS binding after 60 mins by scintillation counting	F	7.37	pIC50	43	nM	IC50	Bioorg Med Chem (2011) 19: 5539-5552 [PMID:21856163]
ChEMBL	Antagonist activity at MCH1R by [35S]GTPgammaS binding assay	F	7.72	pIC50	19	nM	IC50	J Med Chem (2009) 52: 2076-2089 [PMID:19290642]
ChEMBL	Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation counting	B	7.85	pIC50	14	nM	IC50	Bioorg Med Chem (2011) 19: 5539-5552 [PMID:21856163]
ChEMBL	Displacement of [125I]-MCH(4-19) from human MCHR1 expressed in CHO cells	B	8.26	pIC50	5.5	nM	IC50	Bioorg Med Chem (2011) 19: 6261-6273 [PMID:21975069]
ChEMBL	Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cells	B	8.26	pIC50	5.5	nM	IC50	J Med Chem (2004) 47: 3962-3971 [PMID:15267235]
ChEMBL	Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay	F	8.26	pIC50	5.5	nM	IC50	Bioorg Med Chem Lett (2009) 19: 6166-6171 [PMID:19773162]
ChEMBL	Displacement of [125I]MCH from human MCHR1 expressed in CHO cells by competition binding assay	B	8.26	pIC50	5.5	nM	IC50	Bioorg Med Chem (2011) 19: 883-893 [PMID:21190859]
GtoPdb	-	-	8.3	pIC50	5.01	nM	IC50	Eur J Pharmacol (2002) 438: 129-35 [PMID:11909603]
MCH1 receptor/Melanin-concentrating hormone receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075228] [GtoPdb: 280] [UniProtKB: P97639]
ChEMBL	Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting	B	7.62	pIC50	24	nM	IC50	Bioorg Med Chem (2011) 19: 5539-5552 [PMID:21856163]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]