ChEMBL ligand: CHEMBL1231573
RocR in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) [ChEMBL: CHEMBL2396510] [UniProtKB: Q9HX69] There should be some charts here, you may need to enable JavaScript!
stimulator of interferon response cGAMP interactor 1/Stimulator of interferon genes protein in Human [ChEMBL: CHEMBL4523377] [GtoPdb: 2902] [UniProtKB: Q86WV6] stimulator of interferon response cGAMP interactor 1/Stimulator of interferon genes protein in Mouse [ChEMBL: CHEMBL4523311] [GtoPdb: 2902] [UniProtKB: Q3TBT3] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
RocR in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2396510] [UniProtKB: Q9HX69]
ChEMBL	Competitive binding affinity to Pseudomonas aeruginosa PAO1 His6-tagged RocR expressed in Escherichia coli BL21 (DE3) after 5 mins in presence of [32P]-c-di-GMP	B	7.7	pIC50	20	nM	IC50	Bioorg Med Chem (2013) 21: 4396-4404 [PMID:23685177]
stimulator of interferon response cGAMP interactor 1/Stimulator of interferon genes protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523377] [GtoPdb: 2902] [UniProtKB: Q86WV6]
ChEMBL	Binding affinity to human C-terminal STING domain (139 to 379 residues) by isothermal titration calorimetric method	B	5.28	pKd	5200	nM	Kd	Medchemcomm (2019) 10: 1999-2023 [PMID:32206239]
ChEMBL	Binding affinity to wild type human STING (139 to 379 residues) by ITC assay	B	5.92	pKd	1210	nM	Kd	J Med Chem (2020) 63: 3785-3816 [PMID:31820978]
ChEMBL	Binding affinity to human STING expressed in Escherichia coli by isothermal titration calorimetric method	B	5.92	pKd	1210	nM	Kd	Medchemcomm (2019) 10: 1999-2023 [PMID:32206239]
ChEMBL	Agonist activity at wild type human STING C-terminal domain (139 to 379 residues) assessed as dissociation constant by isothermal titration calorimetry analysis	B	5.92	pKd	1210	nM	Kd	Eur J Med Chem (2022) 238: 114482-114482 [PMID:35671593]
ChEMBL	Activation of recombinant human STING haplotype R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay	B	4.35	pEC50	>45000	nM	EC50	J Med Chem (2019) 62: 10676-10690 [PMID:31715099]
ChEMBL	Activation of recombinant human wild-type STING expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay	B	5.35	pEC50	4500	nM	EC50	J Med Chem (2019) 62: 10676-10690 [PMID:31715099]
ChEMBL	Activation of wild-type human STING expressed in digitonin treated HEK293T cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activation by luciferase reporter gene assay	B	5.35	pEC50	4470	nM	EC50	J Med Chem (2021) 64: 7596-7616 [PMID:34019405]
ChEMBL	Activation of recombinant human STING haplotype G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay	B	5.96	pEC50	1100	nM	EC50	J Med Chem (2019) 62: 10676-10690 [PMID:31715099]
ChEMBL	Activation of human STING QA mutant expressed in digitonin treated HEK293T cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activation by luciferase reporter gene assay	B	5.98	pEC50	1050	nM	EC50	J Med Chem (2021) 64: 7596-7616 [PMID:34019405]
ChEMBL	Activation of recombinant human STING haplotype R71H/G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay	B	6.05	pEC50	900	nM	EC50	J Med Chem (2019) 62: 10676-10690 [PMID:31715099]
ChEMBL	Activation of human STING HAQ mutant expressed in digitonin treated HEK293T cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activation by luciferase reporter gene assay	B	6.05	pEC50	890	nM	EC50	J Med Chem (2021) 64: 7596-7616 [PMID:34019405]
stimulator of interferon response cGAMP interactor 1/Stimulator of interferon genes protein in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523311] [GtoPdb: 2902] [UniProtKB: Q3TBT3]
ChEMBL	Binding affinity to mouse C-terminal STING domain (139 to 378 residues) by isothermal titration calorimetric method	B	6.96	pKd	110	nM	Kd	Medchemcomm (2019) 10: 1999-2023 [PMID:32206239]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]