ERAS-5024 [Ligand Id: 12988] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| MRGPRX2 in Human [GtoPdb: 157] [UniProtKB: Q96LB1] | ||||||||
| GtoPdb | - | - | 5.38 | pEC50 | 4200 | nM | EC50 | Toxicol Appl Pharmacol (2023) 474: 116601 [PMID:37321326] |
| KRAS in Human [GtoPdb: 2824] [UniProtKB: P01116] | ||||||||
| GtoPdb | Measuring inhibition of binding of wild type KRAS to RAF Ras binding domain | - | 8.41 | pIC50 | 3.9 | nM | IC50 | ACS Med Chem Lett (2023) 14: 1351-1357 [PMID:37849557] |
| GtoPdb | Measuring inhibition of binding of KRAS G12D to RAF Ras binding domain | - | 9.07 | pIC50 | 0.86 | nM | IC50 | ACS Med Chem Lett (2023) 14: 1351-1357 [PMID:37849557] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
