suzetrigine [Ligand Id: 12630] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Nav1.8 in Human [GtoPdb: 585] [UniProtKB: Q9Y5Y9] | ||||||||
| GtoPdb | Binding affinity for purified NaV1.8 VSD2 chimera protein | - | 7.19 | pKd | 65 | nM | Kd | Pain Ther (2025) 14: 655-674 [PMID:39775738] |
| GtoPdb | Inhibition of human NaV1,8 channels expressed in HEK293 cells. | - | 8 | pIC50 | <10 | nM | IC50 | WO2021113627A1. Substituted tetrahydrofurans as modulators of sodium channels (2021) |
| GtoPdb | - | - | 9.57 | pIC50 | 0.27 | nM | IC50 |
Mol Pharmacol (2024) 106: 298-308 [PMID:39322410]; J Gen Physiol (2025) 157: [PMID:40136042] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
