ACT-777991 [Ligand Id: 12584] activity data from GtoPdb

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  • CXCR3 in Human [GtoPdb: 70] [UniProtKB: P49682]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CXCR3 in Human [GtoPdb: 70] [UniProtKB: P49682]
GtoPdb Binding affinity determined in an association assay using [3H]ACT-777991 - 8.34 pKd 4.6 nM Kd J Med Chem (2023) 66: 4179-4196 [PMID:36883854]
GtoPdb Antagonism of CXCL9-mediated CXCR3 activation in a calcium signaling assay - 8.48 pIC50 3.3 nM IC50 J Med Chem (2023) 66: 4179-4196 [PMID:36883854]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.