oxoglaucine [Ligand Id: 12559] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL470881
  • Monoamine oxidase A/Amine oxidase [flavin-containing] A in Human [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397]
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  • Monoamine oxidase B/Amine oxidase [flavin-containing] B in Human [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338]
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  • TRPV5 in Human [GtoPdb: 511] [UniProtKB: Q9NQA5]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Monoamine oxidase A/Amine oxidase [flavin-containing] A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397]
ChEMBL Inhibition of recombinant human MAO-A using kynuramine as substrate incubated for 20 mins by spectrophotometric method B 4.7 pIC50 >20000 nM IC50 Bioorg Med Chem Lett (2018) 28: 2403-2407 [PMID:29925480]
Monoamine oxidase B/Amine oxidase [flavin-containing] B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338]
ChEMBL Inhibition of recombinant human MAO-B using benzylamine as substrate incubated for 30 mins by spectrophotometric method B 4.7 pIC50 >20000 nM IC50 Bioorg Med Chem Lett (2018) 28: 2403-2407 [PMID:29925480]
Translocator protein in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4552] [GtoPdb: 2879] [UniProtKB: P16257]
ChEMBL Inhibition of rat TSPO B 6.52 pIC50 300 nM IC50 Eur J Med Chem (2024) 267: 116117-116117 [PMID:38295689]
TRPV5 in Human [GtoPdb: 511] [UniProtKB: Q9NQA5]
GtoPdb - - 4.82 pIC50 15000 nM IC50 Br J Pharmacol (2021) 178: 2931-2947 [PMID:33786819]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]