ChEMBL ligand: CHEMBL2334586
mitogen-activated protein kinase kinase kinase 14 in Human [GtoPdb: 2074] [UniProtKB: Q99558] There should be some charts here, you may need to enable JavaScript!
p21 (RAC1) activated kinase 4 in Human [GtoPdb: 2136] [UniProtKB: O96013] There should be some charts here, you may need to enable JavaScript!
p21 (RAC1) activated kinase 6 in Human [GtoPdb: 2137] [UniProtKB: Q9NQU5] There should be some charts here, you may need to enable JavaScript!
p21 (RAC1) activated kinase 5 in Human [GtoPdb: 2138] [UniProtKB: Q9P286] There should be some charts here, you may need to enable JavaScript!
TAO kinase 1 in Human [GtoPdb: 2233] [UniProtKB: Q7L7X3] There should be some charts here, you may need to enable JavaScript!
TAO kinase 2 in Human [GtoPdb: 2234] [UniProtKB: Q9UL54] There should be some charts here, you may need to enable JavaScript!
TAO kinase 3 in Human [GtoPdb: 2235] [UniProtKB: Q9H2K8] There should be some charts here, you may need to enable JavaScript!
tau tubulin kinase 1 in Human [GtoPdb: 2262] [UniProtKB: Q5TCY1] There should be some charts here, you may need to enable JavaScript!
phosphoinositide kinase, FYVE-type zinc finger containing in Human [GtoPdb: 2857] [UniProtKB: Q9Y2I7] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
mitogen-activated protein kinase kinase kinase 14 in Human [GtoPdb: 2074] [UniProtKB: Q99558]
GtoPdb	Enzymatic inhibition determined in a homogenous time resolved fluorescence (HTRF) assay for NIK (MAP3K14)	-	6	pKi	<1000	nM	Ki	WO2009158011A1. Alkynyl alcohols as kinase inhibitors (2009)
p21 (RAC1) activated kinase 4 in Human [GtoPdb: 2136] [UniProtKB: O96013]
GtoPdb	-	-	6.96	pIC50	110	nM	IC50	J Med Chem (2022) 65: 12860-12882 [PMID:36111834]
p21 (RAC1) activated kinase 6 in Human [GtoPdb: 2137] [UniProtKB: Q9NQU5]
GtoPdb	-	-	7.22	pIC50	60	nM	IC50	J Med Chem (2022) 65: 12860-12882 [PMID:36111834]
p21 (RAC1) activated kinase 5 in Human [GtoPdb: 2138] [UniProtKB: Q9P286]
GtoPdb	-	-	7.02	pIC50	96	nM	IC50	J Med Chem (2022) 65: 12860-12882 [PMID:36111834]
TAO kinase 1 in Human [GtoPdb: 2233] [UniProtKB: Q7L7X3]
GtoPdb	-	-	7.7	pIC50	20	nM	IC50	J Med Chem (2022) 65: 12860-12882 [PMID:36111834]
TAO kinase 2 in Human [GtoPdb: 2234] [UniProtKB: Q9UL54]
GtoPdb	-	-	7.04	pIC50	91	nM	IC50	J Med Chem (2022) 65: 12860-12882 [PMID:36111834]
TAO kinase 3 in Human [GtoPdb: 2235] [UniProtKB: Q9H2K8]
GtoPdb	-	-	7.35	pIC50	45	nM	IC50	J Med Chem (2022) 65: 12860-12882 [PMID:36111834]
tau tubulin kinase 1 in Human [GtoPdb: 2262] [UniProtKB: Q5TCY1]
GtoPdb	-	-	6.7	pIC50	199	nM	IC50	J Med Chem (2021) 64: 6358-6380 [PMID:33944571]
phosphoinositide kinase, FYVE-type zinc finger containing in Human [GtoPdb: 2857] [UniProtKB: Q9Y2I7]
GtoPdb	-	-	8.66	pIC50	2.2	nM	IC50	J Med Chem (2022) 65: 12860-12882 [PMID:36111834]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]