exarafenib [Ligand Id: 12095] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| A-Raf proto-oncogene, serine/threonine kinase in Human [GtoPdb: 1933] [UniProtKB: P10398] | ||||||||
| GtoPdb | - | - | 8.62 | pIC50 | 2.4 | nM | IC50 | J Med Chem (2024) : |
| B-Raf proto-oncogene, serine/threonine kinase in Human [GtoPdb: 1943] [UniProtKB: P15056] | ||||||||
| GtoPdb | - | - | 8.46 | pIC50 | 3.5 | nM | IC50 | J Med Chem (2024) : |
| Raf-1 proto-oncogene, serine/threonine kinase in Human [GtoPdb: 2184] [UniProtKB: P04049] | ||||||||
| GtoPdb | Inhibition potency vs. RAF1 was determined in a proprietary ADP-Glo assay | - | 8 | pIC50 | <10 | nM | IC50 | WO2021081375A1. Inhibitors of raf kinases (2021) |
| GtoPdb | - | - | 8.85 | pIC50 | 1.4 | nM | IC50 | J Med Chem (2024) : |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
