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ChEMBL ligand: CHEMBL579394 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
GtoPdb | Determined in an intracellular cAMP accumulation assay in CHO-K1 cells expressing hβ1-AR | - | 9.22 | pEC50 | 0.6 | nM | EC50 |
Bioorg Med Chem Lett (2009) 19: 6640-4 [PMID:19875286]; Cell Res (2021) 31: 569-579 [PMID:33093660] |
ChEMBL | Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation | F | 9.22 | pEC50 | 0.6 | nM | EC50 | Bioorg Med Chem Lett (2009) 19: 6640-6644 [PMID:19875286] |
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
GtoPdb | Determined in an intracellular cAMP accumulation assay in CHO-K1 cells expressing hβ2-AR | - | 10 | pEC50 | 0.1 | nM | EC50 | Bioorg Med Chem Lett (2009) 19: 6640-4 [PMID:19875286] |
ChEMBL | Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation | F | 10 | pEC50 | 0.1 | nM | EC50 | Bioorg Med Chem Lett (2009) 19: 6640-6644 [PMID:19875286] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]