BI-167107 [Ligand Id: 12065] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL579394
  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
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  • β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
GtoPdb Determined in an intracellular cAMP accumulation assay in CHO-K1 cells expressing hβ1-AR - 9.22 pEC50 0.6 nM EC50 Bioorg Med Chem Lett (2009) 19: 6640-4 [PMID:19875286];
Cell Res (2021) 31: 569-579 [PMID:33093660]
ChEMBL Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation F 9.22 pEC50 0.6 nM EC50 Bioorg Med Chem Lett (2009) 19: 6640-6644 [PMID:19875286]
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
GtoPdb Determined in an intracellular cAMP accumulation assay in CHO-K1 cells expressing hβ2-AR - 10 pEC50 0.1 nM EC50 Bioorg Med Chem Lett (2009) 19: 6640-4 [PMID:19875286]
ChEMBL Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation F 10 pEC50 0.1 nM EC50 Bioorg Med Chem Lett (2009) 19: 6640-6644 [PMID:19875286]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]