BI-3406 [Ligand Id: 12061] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL4519023 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| SOS Ras/Rac guanine nucleotide exchange factor 1/Son of sevenless homolog 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2079846] [GtoPdb: 3096] [UniProtKB: Q07889] | ||||||||
| ChEMBL | Binding affinity to SOS1 (unknown origin) assessed as dissociation constant by SPR analysis | B | 8.52 | pKd | 3 | nM | Kd | J Med Chem (2021) 64: 6569-6580 [PMID:33719426] |
| GtoPdb | Binding affinity determined by SPR | - | 8.01 | pKi | 9.7 | nM | Ki | Cancer Discov (2021) 11: 142-157 [PMID:32816843] |
| ChEMBL | Inhibition of SOS1-mediated proliferation of human NCI-H520 cells assessed as proliferation incubated for 5 to 14 days by AlamarBlue based 3D proliferation assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2021) 64: 6569-6580 [PMID:33719426] |
| ChEMBL | Inhibition of SOS1-mediated proliferation of human DLD-1 cells assessed as proliferation incubated for 5 to 14 days by AlamarBlue based 3D proliferation assay | B | 7.44 | pIC50 | 36 | nM | IC50 | J Med Chem (2021) 64: 6569-6580 [PMID:33719426] |
| ChEMBL | Inhibition of GST-tagged SOS1 (564 to 1049 amino acids) (unknown origin) assessed as reduction SOS1/6xHis-Tev-tagged K-Ras G12D mutant (1 to 169 residues) interaction incubated for 30 mins by AlphaLISA method | B | 8.3 | pIC50 | 5 | nM | IC50 | WO-2018115380-A1. Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors (null) |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
