EMDT [Ligand Id: 12] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL267615
  • NET/Norepinephrine transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
  • This target only has 1 pki data point
  • 5
1 CHEMBL267615_lig_chart_1 Norepinephrine transporter Human
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
  • 0
2 CHEMBL267615_lig_chart_2 Serotonin 1a (5-HT1a) receptor HumanRat
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  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
  • This target only has 0 pki data point
  • 0
3 CHEMBL267615_lig_chart_3 Serotonin 1b (5-HT1b) receptor Rat
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  • 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
  • 6.52
4 CHEMBL267615_lig_chart_4 Serotonin 1d (5-HT1d) receptor Human
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  • 5-ht1e receptor/Serotonin 1e (5-HT1e) receptor in Human [ChEMBL: CHEMBL2182] [GtoPdb: 4] [UniProtKB: P28566]
  • 6.29
5 CHEMBL267615_lig_chart_5 Serotonin 1e (5-HT1e) receptor Human
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  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
  • This target only has 1 pki data point
  • 5
6 CHEMBL267615_lig_chart_6 Serotonin 2a (5-HT2a) receptor HumanRat
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  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909]
  • This target only has 1 pki data point
  • 5.74
7 CHEMBL267615_lig_chart_7 Serotonin 2c (5-HT2c) receptor HumanRat
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  • 5-HT3A/Serotonin 3a (5-HT3a) receptor in Human [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
  • This target only has 0 pki data point
  • 0
8 CHEMBL267615_lig_chart_8 Serotonin 3a (5-HT3a) receptor Human
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  • Serotonin 4 (5-HT4) receptor in Guinea pig [ChEMBL: CHEMBL5017] [UniProtKB: O70528]
  • This target only has 0 pki data point
  • 0
9 CHEMBL267615_lig_chart_9 Serotonin 4 (5-HT4) receptor Guinea pig
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  • 5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898]
  • 5.32
10 CHEMBL267615_lig_chart_10 Serotonin 5a (5-HT5a) receptor Human
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  • 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
  • 7.8
11 CHEMBL267615_lig_chart_11 Serotonin 6 (5-HT6) receptor Human
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  • 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
  • 6.51
12 CHEMBL267615_lig_chart_12 Serotonin 7 (5-HT7) receptor Human
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  • SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
  • This target only has 1 pki data point
  • 5
13 CHEMBL267615_lig_chart_13 Serotonin transporter Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
ChEMBL Compound was evaluated for its binding affinity towards human NET(norepinephrine) transporter B 5 pKi >10000 nM Ki J. Med. Chem. (2000) 43: 1011-1018 [PMID:10715164]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1A receptor B 6.77 pKi 170 nM Ki J. Med. Chem. (2000) 43: 1011-1018 [PMID:10715164]
GtoPdb - - 6.8 pKi - - - J Med Chem (2000) 43: 1011-8 [PMID:10715164]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL Inhibitory activity against 5-hydroxytryptamine 1A receptor in rat B 6 pIC50 >1000 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 3230-4234 [PMID:16055331]
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
ChEMBL Inhibitory activity against 5-hydroxytryptamine 1B receptor in rat B 6 pIC50 >1000 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 3230-4234 [PMID:16055331]
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
GtoPdb - - 6.5 pKi - - - J Med Chem (2000) 43: 1011-8 [PMID:10715164]
ChEMBL Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptor B 6.54 pKi 290 nM Ki J. Med. Chem. (2000) 43: 1011-1018 [PMID:10715164]
ChEMBL Inhibitory activity against 5-hydroxytryptamine 1D receptor in calf B 5.85 pIC50 1400 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 3230-4234 [PMID:16055331]
5-ht1e receptor/Serotonin 1e (5-HT1e) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2182] [GtoPdb: 4] [UniProtKB: P28566]
ChEMBL Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1E receptor B 6.28 pKi 520 nM Ki J. Med. Chem. (2000) 43: 1011-1018 [PMID:10715164]
GtoPdb - - 6.3 pKi - - - J Med Chem (2000) 43: 1011-8 [PMID:10715164]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL Inhibitory activity against 5-hydroxytryptamine 2A receptor in human B 6.21 pIC50 620 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 3230-4234 [PMID:16055331]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
ChEMBL Compound was evaluated for its binding affinity towards rat 5-hydroxytryptamine 2A receptor B 5 pKi >10000 nM Ki J. Med. Chem. (2000) 43: 1011-1018 [PMID:10715164]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL Inhibitory activity against 5-hydroxytryptamine 2C receptor in human B 5.26 pIC50 5500 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 3230-4234 [PMID:16055331]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909]
ChEMBL Compound was evaluated for its binding affinity towards rat 5-hydroxytryptamine 2C receptor B 5.74 pKi 1810 nM Ki J. Med. Chem. (2000) 43: 1011-1018 [PMID:10715164]
5-HT3A/Serotonin 3a (5-HT3a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
ChEMBL Inhibitory activity against 5-hydroxytryptamine 3 receptor expressed in NG 108 cells B 6 pIC50 >1000 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 3230-4234 [PMID:16055331]
Serotonin 4 (5-HT4) receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5017] [UniProtKB: O70528]
ChEMBL Inhibitory activity against 5-hydroxytryptamine 4 receptor in guinea pig B 7.36 pIC50 44 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 3230-4234 [PMID:16055331]
5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898]
GtoPdb - - 5.3 pKi - - - J Med Chem (2000) 43: 1011-8 [PMID:10715164]
ChEMBL Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 5A receptor B 5.34 pKi 4620 nM Ki J. Med. Chem. (2000) 43: 1011-1018 [PMID:10715164]
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL Binding affinity for human 5-hydroxytryptamine 6 receptor expressed in HEK 293 human embryonic kidney cells, [3H]-lysergic acid diethylamide as radioligand B 7.28 pKi 52 nM Ki J. Med. Chem. (2000) 43: 1011-1018 [PMID:10715164]
ChEMBL Binding affinity for human 5-hydroxytryptamine 6 receptor B 7.3 pKi <50 nM Ki J. Med. Chem. (2005) 48: 1781-1795 [PMID:15771424]
ChEMBL Binding affinity against 5 Hydroxy tryptamine 6 receptor B 7.8 pKi 16 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 1707-1711 [PMID:15745826]
ChEMBL Binding affinity against 5-hydroxytryptamine 6 receptor B 7.8 pKi 16 nM Ki Bioorg. Med. Chem. Lett. (2004) 14: 4569-4573 [PMID:15357994]
ChEMBL Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells B 7.8 pKi 16 nM Ki J. Med. Chem. (2008) 51: 603-611 [PMID:18201064]
ChEMBL Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells by liquid scintillation counting B 7.8 pKi 16 nM Ki J. Med. Chem. (2009) 52: 675-687 [PMID:19159187]
ChEMBL Binding affinity to 5HT6 receptor B 7.8 pKi 16 nM Ki Bioorg. Med. Chem. (2009) 17: 7387-7397 [PMID:19758807]
ChEMBL Binding affinity to 5-HT6 receptor (unknown origin) B 7.8 pKi 16 nM Ki Med Chem Res (2005) 14: 1-18
ChEMBL Binding affinity towards human 5-hydroxytryptamine 6 receptor B 7.8 pKi 16 nM Ki J. Med. Chem. (2003) 46: 2795-2812 [PMID:12825922]
ChEMBL Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor transfected in HEK293 cells after 60 mins by liquid scintillation spectrometry B 7.8 pKi 16 nM Ki J. Med. Chem. (2015) 58: 7901-7912 [PMID:26099069]
ChEMBL Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 6 receptor B 7.8 pKi 16 nM Ki J. Med. Chem. (2000) 43: 1011-1018 [PMID:10715164]
GtoPdb - - 7.8 pKi - - - J Med Chem (2000) 43: 1011-8 [PMID:10715164]
ChEMBL Displacement of [3H]LSD binding to cloned human 5-hydroxytryptamine 6 receptor stably expressed in HEK cells B 7.07 pIC50 85 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 3230-4234 [PMID:16055331]
ChEMBL Inhibitory activity against 5-hydroxytryptamine 6 receptor in human B 7.07 pIC50 85 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 3230-4234 [PMID:16055331]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
GtoPdb - - 6.5 pKi - - - J Med Chem (2000) 43: 1011-8 [PMID:10715164]
ChEMBL Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor B 6.52 pKi 300 nM Ki J. Med. Chem. (2000) 43: 1011-1018 [PMID:10715164]
ChEMBL Inhibitory activity against 5-hydroxytryptamine 7 receptor in human B 5.82 pIC50 1500 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 3230-4234 [PMID:16055331]
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
ChEMBL Compound was evaluated for its binding affinity towards human serotonin transporter B 5 pKi >10000 nM Ki J. Med. Chem. (2000) 43: 1011-1018 [PMID:10715164]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]