vipivotide tetraxetan [Ligand Id: 11982] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4594280 (DKFZ-PSMA-617, PSMA-617, PSMA617, Vipivotide tetraxetan) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Folate hydrolase (prostate-specific membrane antigen) 1/Glutamate carboxypeptidase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1892] [GtoPdb: 1606] [UniProtKB: Q04609] | ||||||||
| GtoPdb | Inhibition of PSMA enzymatic activity | - | 9.43 | pKi | 0.37 | nM | Ki | J Nucl Med (2015) 56: 914-20 [PMID:25883127] |
| ChEMBL | Displacement of [125I]MIP-1095 from PSMA in human PC3-PIP cells after 1 hr by gamma counter analysis | B | 7.96 | pIC50 | 10.9 | nM | IC50 | Bioorg Med Chem (2020) 28: 115319-115319 [PMID:32001090] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
