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ChEMBL ligand: CHEMBL3545043 (Asapiprant, S-555739) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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DP1 receptor/Prostanoid DP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258] | ||||||||
ChEMBL | Displacement of [3H]-PGD2 from PGD2 receptor in human platelet membranes after 2 hrs by micro beta scintillation counting analysis | B | 6.62 | pKi | 240 | nM | Ki | US-8153793-B2. Sulfonamide derivative having PGD2 receptor antagonistic activity (2012) |
GtoPdb | Displacement of [3H]-PGD2 from DP receptor in human platelet membranes | - | 6.62 | pKi | 240 | nM | Ki | US8153793B2. Sulfonamide derivative having PGD2 receptor antagonistic activity (2012) |
ChEMBL | Antagonist activity at PGD2 receptor in human platelets assessed as inhibition of PGD2-mediated cAMP accumulation preincubated for 5 mins followed by PGD2 addition measured after 2 mins by HTRF assay | F | 6.28 | pIC50 | 520 | nM | IC50 | US-8153793-B2. Sulfonamide derivative having PGD2 receptor antagonistic activity (2012) |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]