ensifentrine [Ligand Id: 11865] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4594287 (Ensifentrina, Ensifentrine, Ls-193,855, Ls-193855, RPL-554, RPL554) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| phosphodiesterase 3A in Human [GtoPdb: 1298] [UniProtKB: Q14432] | ||||||||
| GtoPdb | Inhibition of PDE3 from human platelets | - | 9.4 | pIC50 | 0.4 | nM | IC50 | J Pharmacol Exp Ther (2006) 318: 840-8 [PMID:16682455] |
| phosphodiesterase 4A in Human [GtoPdb: 1300] [UniProtKB: P27815] | ||||||||
| GtoPdb | Inhibition of PDE4 obtained from human neutrophils | - | 5.83 | pIC50 | 1479 | nM | IC50 | J Pharmacol Exp Ther (2006) 318: 840-8 [PMID:16682455] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
