tetrandrine [Ligand Id: 11859] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL176045 (NSC-77037)
Created with Highcharts 10.3.3ValuesChart context menuPlasmodium falciparumpKd Plasmodium falciparumpKi Plasmodium falciparumpIC50 Plasmodium falciparumpEC50 Plasmodium falciparum02468Highcharts.com
  • KCa2.2/Small conductance calcium-activated potassium channel protein 2 in Human [ChEMBL: CHEMBL4469] [GtoPdb: 382] [UniProtKB: Q9H2S1]
Created with Highcharts 10.3.3ValuesChart context menuSmall conductance calcium-activated potassium channel protein 2pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Human [ChEMBL: CHEMBL3381] [GtoPdb: 383] [UniProtKB: Q9UGI6]
Created with Highcharts 10.3.3ValuesChart context menuSmall conductance calcium-activated potassium channel protein 3pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs F 6.54 pIC50 288 nM IC50 J Nat Prod (1999) 62: 59-66 [PMID:9917283]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs F 6.59 pIC50 257 nM IC50 J Nat Prod (1999) 62: 59-66 [PMID:9917283]
KCa2.2/Small conductance calcium-activated potassium channel protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4469] [GtoPdb: 382] [UniProtKB: Q9H2S1]
GtoPdb Measuring displacement of [125I]apamin - 6.51 pKi 306 nM Ki ACS Med Chem Lett (2024) 15: 215-220 [PMID:38352826]
ChEMBL Displacement of [125I]apamin from SK2 (unknown origin) expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintillation counting analysis B 6.51 pKi 306 nM Ki ACS Med Chem Lett (2024) 15: 215-220 [PMID:38352826]
KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3381] [GtoPdb: 383] [UniProtKB: Q9UGI6]
ChEMBL Displacement of [125I]apamin from SK3 (unknown origin) expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintillation counting analysis B 6.34 pKi 461 nM Ki ACS Med Chem Lett (2024) 15: 215-220 [PMID:38352826]
GtoPdb Measuring displacement of [125I]apamin - 6.34 pKi 461 nM Ki ACS Med Chem Lett (2024) 15: 215-220 [PMID:38352826]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]