enarodustat [Ligand Id: 11828] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4297619 (JTZ-951, Jtz-951, Enarodustat) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Aspartyl/asparaginyl beta-hydroxylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4680030] [UniProtKB: Q12797] | ||||||||
| ChEMBL | Inhibition of AspH (unknown origin) | B | 5.02 | pIC50 | 9600 | nM | IC50 | J Med Chem (2025) 68: 9777-9798 [PMID:40263713] |
| lysine demethylase 8/Bifunctional peptidase and arginyl-hydroxylase JMJD5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523396] [GtoPdb: 2687] [UniProtKB: Q8N371] | ||||||||
| ChEMBL | Inhibition of JMJD5 (unknown origin) | B | 4.54 | pIC50 | 28900 | nM | IC50 | J Med Chem (2025) 68: 9777-9798 [PMID:40263713] |
| egl-9 family hypoxia inducible factor 1/Egl nine homolog 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5697] [GtoPdb: 2833] [UniProtKB: Q9GZT9] | ||||||||
| ChEMBL | Inhibition of PHD2 (unknown origin) | B | 6.42 | pIC50 | 380 | nM | IC50 | J Med Chem (2025) 68: 9777-9798 [PMID:40263713] |
| GtoPdb | Inhibition of PHD2 enzyme activity in a biochemical assay | - | 6.66 | pIC50 | 220 | nM | IC50 | ACS Med Chem Lett (2017) 8: 1320-1325 [PMID:29259755] |
| Gamma-butyrobetaine dioxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2163175] [UniProtKB: O75936] | ||||||||
| ChEMBL | Inhibition of full-length recombinant human BBOX using GBB/2-OG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by SPE-MS analysis | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2025) 68: 9777-9798 [PMID:40263713] |
| lysine demethylase 4A/Lysine-specific demethylase 4A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5896] [GtoPdb: 2675] [UniProtKB: O75164] | ||||||||
| ChEMBL | Inhibition of KDM4A (unknown origin) | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2025) 68: 9777-9798 [PMID:40263713] |
ChEMBL data shown on this page come from version 37:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
