AZD4604 [Ligand Id: 11716] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL4447181
  • Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458]
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  • Janus kinase 2 in Human [GtoPdb: 2048] [UniProtKB: O60674]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458]
GtoPdb - - 8.52 pIC50 <3 nM IC50 WO2018134213A1. Jak1 selective inhibitors (2018)
Janus kinase 2 in Human [GtoPdb: 2048] [UniProtKB: O60674]
GtoPdb - - 5.91 pIC50 1220 nM IC50 WO2018134213A1. Jak1 selective inhibitors (2018)

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]