ChEMBL ligand: CHEMBL38576 (ICI-199441)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] κ receptor/Kappa opioid receptor in Mouse [ChEMBL: CHEMBL4329] [GtoPdb: 318] [UniProtKB: P33534] Kappa opioid receptor in Guinea pig [ChEMBL: CHEMBL3952] [UniProtKB: P41144] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] Mu opioid receptor in Guinea pig [ChEMBL: CHEMBL4354] [UniProtKB: P97266] There should be some charts here, you may need to enable JavaScript!
UT receptor/Urotensin II receptor in Human [ChEMBL: CHEMBL3764] [GtoPdb: 365] [UniProtKB: Q9UKP6] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Inhibitory constant against human Opioid receptor delta 1 using [3H]diprenorphine as radio ligand	B	7.62	pKi	24	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2647-2652 [PMID:15863335]
ChEMBL	Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO-K1 cells	B	7.62	pKi	24	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3667-3671 [PMID:18487043]
ChEMBL	Tested for inhibitory concentration against [3H]DPDPE binding at sites of delta-opioid receptor in guinea pig brain membrane	B	6.22	pIC50	600	nM	IC50	J Med Chem (1994) 37: 2856-2864 [PMID:8071934]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U-69593	B	10.27	pKi	0.05	nM	Ki	Bioorg Med Chem Lett (2000) 10: 2567-2570 [PMID:11086731]
ChEMBL	Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO-K1 cells	B	10.36	pKi	0.04	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3667-3671 [PMID:18487043]
ChEMBL	In vitro binding affinity for human kappa opioid receptor was determined by using [3H]diprenorphine as radioligand	B	10.37	pKi	0.04	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1279-1282 [PMID:15713370]
ChEMBL	Inhibitory constant against human Opioid receptor kappa using [3H]diprenorphine as radio ligand	B	10.4	pKi	0.04	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2647-2652 [PMID:15863335]
GtoPdb	Displacement of [3H]diprenorphine from human κ opioid receptor	-	10.4	pKi	0.04	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1279-82 [PMID:15713370]
ChEMBL	Agonist activity at kappa opioid receptor	F	9.4	pEC50	0.4	nM	EC50	Bioorg Med Chem Lett (2008) 18: 3716-3719 [PMID:18524591]
ChEMBL	Agonist activity assessed by ability to stimulate [35S]GTP gammaS binding to opioid receptor kappa in human membranes	F	9.52	pEC50	0.3	nM	EC50	Bioorg Med Chem Lett (2005) 15: 2647-2652 [PMID:15863335]
ChEMBL	Agonist activity at human kappa opioid receptor transfected in CHO cells by [35S]GTP-gamma-S binding assay	F	9.52	pEC50	0.3	nM	EC50	Bioorg Med Chem Lett (2008) 18: 3667-3671 [PMID:18487043]
κ receptor/Kappa opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4329] [GtoPdb: 318] [UniProtKB: P33534]
ChEMBL	Inhibitory activity against Opioid receptor kappa 1 in electrically stimulated mouse vas deferens (MVD) preparation.	B	8.6	pIC50	2.5	nM	IC50	J Med Chem (1996) 39: 1729-1735 [PMID:8648612]
Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144]
ChEMBL	Binding affinity against opioid receptor kappa, in guinea pig brain membrane, using [3H]bremazocine as the radioligand.	B	8.16	pIC50	6.9	nM	IC50	J Med Chem (1991) 34: 3149-3158 [PMID:1659636]
ChEMBL	Compound was evaluated for the Opioid receptor kappa 1 affinity using guinea pig brain membranes.	B	8.16	pIC50	6.9	nM	IC50	J Med Chem (1991) 34: 181-189 [PMID:1846918]
ChEMBL	Tested for inhibitory concentration against [3H]U-69593 binding at sites of kappa-opioid receptor in guinea pig brain membrane	B	8.82	pIC50	1.5	nM	IC50	J Med Chem (1994) 37: 2856-2864 [PMID:8071934]
ChEMBL	Inhibitory activity against Opioid receptor kappa 1 in electrically stimulated guinea pig longitudinal ileal muscle (GPI) preparation.	B	9.57	pIC50	0.27	nM	IC50	J Med Chem (1996) 39: 1729-1735 [PMID:8648612]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Inhibitory constant against human Opioid receptor mu 1 using [3H]diprenorphine as radio ligand	B	7.28	pKi	53	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2647-2652 [PMID:15863335]
ChEMBL	Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO-K1 cells	B	7.28	pKi	53	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3667-3671 [PMID:18487043]
GtoPdb	Displacement of [3H]diprenorphine from human μ opioid receptor expressed in CHO-K1 cells	-	7.28	pKi	53	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3667-71 [PMID:18487043]
Mu opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4354] [UniProtKB: P97266]
ChEMBL	Tested for inhibitory concentration against [3H]DAMGO binding at sites of mu-opioid receptor in guinea pig brain membrane	B	6.82	pIC50	150	nM	IC50	J Med Chem (1994) 37: 2856-2864 [PMID:8071934]
UT receptor/Urotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3764] [GtoPdb: 365] [UniProtKB: Q9UKP6]
ChEMBL	Binding affinity to human urotensin-2 receptor	B	5.4	pKi	4000	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3716-3719 [PMID:18524591]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]