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ChEMBL ligand: CHEMBL3353411 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
ChEMBL | Inhibition of wild type EGFR phosphorylation in human LoVo cells after 2 hrs by fluorescence assay | B | 4.48 | pIC50 | 33000 | nM | IC50 | J Med Chem (2014) 57: 8249-8267 [PMID:25271963] |
ChEMBL | Inhibition of EGFR L858R/T970M double mutant phosphorylation in human NCI-H1975 cells after 2 hrs by fluorescence assay | B | 5.7 | pIC50 | 2000 | nM | IC50 | J Med Chem (2014) 57: 8249-8267 [PMID:25271963] |
GtoPdb | Inhibition of wild type EGFR phosphorylation in human LoVo cells | - | 7.48 | pIC50 | 33 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 1861-8 [PMID:26968253] |
ChEMBL | Inhibition of wild type EGFR phosphorylation in human LoVo cells preincubated for 2 hrs followed by EGF stimulation measured after 30 mins by ELISA | B | 7.48 | pIC50 | 33 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 1861-1868 [PMID:26968253] |
ChEMBL | Inhibition of EGFR T790M/L858R double mutant phosphorylation in human H1975 cells preincubated for 2 hrs by ELISA | B | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 1861-1868 [PMID:26968253] |
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Inhibition of human ERG | B | 4.76 | pIC50 | 17500 | nM | IC50 | J Med Chem (2014) 57: 8249-8267 [PMID:25271963] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]