BRD9185 [Ligand Id: 11469] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL4064731
  • dihydroorotate dehydrogenase (quinone)/Dihydroorotate dehydrogenase in Human [ChEMBL: CHEMBL1966] [GtoPdb: 2604] [UniProtKB: Q02127]
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  • Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum [GtoPdb: 2949]
  • Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum Dd2 [GtoPdb: 2949]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
dihydroorotate dehydrogenase (quinone)/Dihydroorotate dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1966] [GtoPdb: 2604] [UniProtKB: Q02127]
GtoPdb - - 4.3 pIC50 >50000 nM IC50 ACS Med Chem Lett (2017) 8: 438-442 [PMID:28435533]
ChEMBL Inhibition of recombinant human DHODH B 4.3 pIC50 >50000 nM IC50 ACS Med Chem Lett (2017) 8: 438-442 [PMID:28435533]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 infected in human blood after 72 hrs by SYBR Green dye based assay F 7.8 pEC50 16 nM EC50 ACS Med Chem Lett (2017) 8: 438-442 [PMID:28435533]
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum [GtoPdb: 2949]
GtoPdb - - 7.92 pIC50 12 nM IC50 ACS Med Chem Lett (2017) 8: 438-442 [PMID:28435533]
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum Dd2 [GtoPdb: 2949]
GtoPdb Parasite growth inhibition assay - 7.8 pEC50 16 nM EC50 ACS Med Chem Lett (2017) 8: 438-442 [PMID:28435533]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]