HET0016 [Ligand Id: 11373] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL267865
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  • CYP4F12 in Human [GtoPdb: 1348] [UniProtKB: Q9HCS2]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cyclooxygenase-2 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4102] [UniProtKB: P79208]
ChEMBL Tested for inhibitory activity against Prostaglandin G/H synthase B 5.64 pIC50 2300 nM IC50 Bioorg Med Chem Lett (2001) 11: 2993-2995 [PMID:11714595]
CYP2C19/Cytochrome P450 2C19 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3622] [GtoPdb: 1328] [UniProtKB: P33261]
ChEMBL Inhibition of cytochrome P450 CYP2C19 B 6.57 pIC50 272 nM IC50 J Med Chem (2003) 46: 5416-5427 [PMID:14640550]
CYP4F12 in Human [GtoPdb: 1348] [UniProtKB: Q9HCS2]
GtoPdb - - 7.86 pIC50 13.7 nM IC50 J Pharmacol Exp Ther (2018) 366: 446-457 [PMID:29976573]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]