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ChEMBL ligand: CHEMBL56337 (Aldonil, Aldorin, Epalrestat, Kinedak, Tanglin) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Aldehyde reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2246] [UniProtKB: P14550] | ||||||||
ChEMBL | Inhibition of N-terminal 6His-tagged human aldehyde reductase expressed in Escherichia coli BL21(DE3) mediated D-glucuronate reduction | B | 5.59 | pIC50 | 2600 | nM | IC50 | Bioorg Med Chem (2010) 18: 2485-2490 [PMID:20304656] |
ChEMBL | Inhibition of human recombinant AKR1A1 expressed in Escherichia coli BL21 cells using D-glucuronate as substrate by spectrophotometry | B | 5.59 | pIC50 | 2600 | nM | IC50 | Bioorg Med Chem (2012) 20: 356-367 [PMID:22104435] |
Aldehyde reductase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4049] [UniProtKB: P50578] | ||||||||
ChEMBL | Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase values | B | 5.82 | pIC50 | 1500 | nM | IC50 | J Med Chem (1991) 34: 1011-1018 [PMID:1900532] |
Aldehyde reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3871] [UniProtKB: P51635] | ||||||||
ChEMBL | In vitro inhibitory activity against rat kidney aldehyde reductase(ALR). | B | 5.82 | pIC50 | 1500 | nM | IC50 | J Med Chem (1997) 40: 684-694 [PMID:9057855] |
Aldo-keto reductase family 1 member B10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5983] [UniProtKB: O60218] | ||||||||
ChEMBL | Inhibition of reductase activity of N-terminal 6His-tagged AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as inhibition of NADPH linked pyridine-3-aldehyde reduction | B | 6.48 | pIC50 | 330 | nM | IC50 | Bioorg Med Chem (2010) 18: 2485-2490 [PMID:20304656] |
ChEMBL | Inhibition of recombinant N-His6-tagged AKR1B10 expressed in Escherichia coli BL21 cells using pyridine-3-aldehyde as substrate by spectrophotometry | B | 6.48 | pIC50 | 330 | nM | IC50 | Bioorg Med Chem (2012) 20: 356-367 [PMID:22104435] |
ChEMBL | Inhibition of AKR1B10 (unknown origin) pretreated with 0.42M DMSO followed by compound treatment by DMSO-perturbation assay | B | 7.41 | pIC50 | 39.3 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 126815-126815 [PMID:31744675] |
ChEMBL | Inhibition of AKR1B10 (unknown origin) pretreated with 0.25M DMSO followed by compound treatment by DMSO-perturbation assay | B | 7.45 | pIC50 | 35.2 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 126815-126815 [PMID:31744675] |
aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121] | ||||||||
ChEMBL | Inhibition human recombinant aldose reductase 1 by spectrophotometric analysis | B | 4.9 | pIC50 | 12500 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 5630-5633 [PMID:20805028] |
ChEMBL | Inhibition of human recombinant ALR2 expressed in Escherichia coli using DL-glyceraldehyde as substrate and NADPH preincubated for 5 mins followed by substrate addition and measured after 30 mins at 2 mins interval by spectrophotometry relative to control | B | 6.21 | pIC50 | 620 | nM | IC50 | Eur J Med Chem (2019) 168: 154-175 [PMID:30818176] |
ChEMBL | Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.7M DMSO followed by compound addition by DMSO-perturbation assay | B | 6.82 | pIC50 | 150 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 126815-126815 [PMID:31744675] |
ChEMBL | Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.3M DMSO followed by compound addition by DMSO-perturbation assay | B | 6.96 | pIC50 | 110 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 126815-126815 [PMID:31744675] |
ChEMBL | Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction incubated in sodium phosphate buffer at pH 6.2 in presence of NADPH | B | 6.96 | pIC50 | 110 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 126815-126815 [PMID:31744675] |
ChEMBL | Inhibition of human recombinant aldose reductase expressed in Escherichia coli BL21 (DE3) pLysS assessed as reduction in NADPH oxidation using L-idose as substrate | B | 6.99 | pIC50 | 102 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 3712-3720 [PMID:30342956] |
ChEMBL | Inhibition of human recombinant AKR1B1 expressed in Escherichia coli BL21 cells using pyridine-3-aldehyde as substrate by spectrophotometry | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem (2012) 20: 356-367 [PMID:22104435] |
ChEMBL | Inhibition of aldose reductase (unknown origin) | B | 7.03 | pIC50 | 93.9 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 4482-4487 [PMID:28802633] |
ChEMBL | Inhibition of recombinant human ALR2 assessed as reduction in NADPH oxidation measured for 5 mins in presence of D,L-glyceraldehyde by spectrophotometric method | B | 7.07 | pIC50 | 85 | nM | IC50 | Eur J Med Chem (2017) 125: 965-974 [PMID:27769036] |
ChEMBL | Inhibition of recombinant human ALR2 using D,L-glyceraldehyde and NADPH as substrate preincubated for 3 mins followed by substrate addition and measured for 3 mins by spectrophotometric analysis | B | 7.18 | pIC50 | 66.5 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 4870-4874 [PMID:27666634] |
ChEMBL | Inhibition of N-terminal 6His-tagged human aldose reductase expressed in Escherichia coli BL21(DE3) mediated NADPH linked pyridine-3-aldehyde reduction | B | 7.68 | pIC50 | 21 | nM | IC50 | Bioorg Med Chem (2010) 18: 2485-2490 [PMID:20304656] |
ChEMBL | Inhibitory activity against aldose reductase enzyme | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2003) 46: 417-426 [PMID:12540241] |
Aldose reductase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3081] [UniProtKB: P16116] | ||||||||
ChEMBL | Inhibition of bovine lens aldose reductase assessed as inhibition of NDAPH oxidation by non-linear regression analysis | B | 6.77 | pIC50 | 170 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 200-203 [PMID:21129963] |
ChEMBL | Inhibition of bovine lens ALR2 | B | 6.77 | pIC50 | 170 | nM | IC50 | Eur J Med Chem (2011) 46: 2797-2806 [PMID:21531055] |
ChEMBL | Inhibition of bovine aldose reductase assessed as oxidation of NADPH | B | 6.77 | pIC50 | 170 | nM | IC50 | Eur J Med Chem (2014) 81: 1-14 [PMID:24819954] |
aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] | ||||||||
ChEMBL | Inhibition of Wistar rat kidney ALR1 assessed as reduction in NADPH oxidation using sodium D-glucuronate and NADPH as substrate preincubated for 10 mins followed by substrate addition and measured for 4 mins by spectrophotometric analysis | B | 5.3 | pIC50 | 5000 | nM | IC50 | Eur J Med Chem (2021) 215: 113269-113269 [PMID:33588177] |
ChEMBL | Inhibition of rat kidney ALR1 using DL-glyceraldehyde as substrate and NADPH preincubated for 5 mins followed by substrate addition and measured for 30 mins at 2 mins interval by spectrophotometry relative to control | B | 5.49 | pIC50 | 3210 | nM | IC50 | Eur J Med Chem (2019) 168: 154-175 [PMID:30818176] |
ChEMBL | Inhibition of Wistar rat kidney ALR1 using sodium D-glucuronate as substrate preincubated for 10 mins followed by substrate addition and measured for 4 mins by spectrophotometric method | B | 5.65 | pIC50 | 2257 | nM | IC50 | Bioorg Med Chem (2019) 27: 1658-1669 [PMID:30858026] |
ChEMBL | In vitro inhibitory activity against rat kidney Aldehyde reductase | B | 5.82 | pIC50 | 1500 | nM | IC50 | J Med Chem (1996) 39: 1924-1927 [PMID:8627616] |
ChEMBL | Inhibition of ALR2 in rat sciatic nerve assessed as reduction in sorbitol accumulation incubated for 3 hrs in presence of 28 mM glucose by gas chromatographic analysis | B | 6.07 | pIC50 | 860 | nM | IC50 | Eur J Med Chem (2019) 168: 154-175 [PMID:30818176] |
ChEMBL | Inhibition of ALR2 in rat lens assessed as reduction in sorbitol accumulation incubated for 3 hrs in presence of 28 mM glucose by gas chromatographic analysis relative to control | B | 6.28 | pIC50 | 530 | nM | IC50 | Eur J Med Chem (2019) 168: 154-175 [PMID:30818176] |
ChEMBL | Inhibition of ALR2 in rat erythrocytes assessed as reduction in sorbitol accumulation incubated for 3 hrs in presence of 28 mM glucose by gas chromatographic analysis relative to control | B | 6.29 | pIC50 | 510 | nM | IC50 | Eur J Med Chem (2019) 168: 154-175 [PMID:30818176] |
ChEMBL | Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometry | B | 6.6 | pIC50 | 250 | nM | IC50 | J Med Chem (2015) 58: 2649-2657 [PMID:25695864] |
ChEMBL | Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition measured after 4 mins by spectrophotometric analysis | B | 6.64 | pIC50 | 227 | nM | IC50 | Bioorg Med Chem (2017) 25: 6353-6360 [PMID:29074349] |
ChEMBL | Inhibition of Sprague-Dawley albino rat ALR2 assessed as enzyme-mediated oxidation of NADPH using D,L-glyceraldehyde as substrate by spectrophotometric analysis | B | 6.77 | pIC50 | 170 | nM | IC50 | Eur J Med Chem (2012) 51: 216-226 [PMID:22436396] |
ChEMBL | Inhibition of Sprague-Dawley albino rat lens ALR2 by spectrophotometry | B | 6.77 | pIC50 | 170 | nM | IC50 | J Med Chem (2012) 55: 10523-10531 [PMID:23134227] |
ChEMBL | Inhibition of ALR2 from rat lens using D,L-glyceraldehyde as substrate measured as absorption of NADPH for 4 mins by UV/vis spectrophotmetry | B | 6.89 | pIC50 | 130 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 2880-2885 [PMID:27156769] |
ChEMBL | Inhibition of Wistar rat lens ALR2 using D,L-glyceraldehyde as substrate after 10 mins by UV/VIS double spectrophotometric analysis | B | 6.92 | pIC50 | 120 | nM | IC50 | Bioorg Med Chem (2011) 19: 7262-7269 [PMID:22036211] |
ChEMBL | Inhibition of Wistar rat eye lens aldose reductase-2 using D-L glyceraldehyde as substrate assessed as oxidation of NADPH preincubated for 10 mins followed by substrate addition measured for 4 mins by spectrophotometric analysis | B | 6.92 | pIC50 | 120 | nM | IC50 | Eur J Med Chem (2014) 80: 383-392 [PMID:24793885] |
ChEMBL | Inhibition of Wistar rat lens ALR2 assessed as reduction in NADPH oxidation using D,L-glyceraldehyde and NADPH as substrate preincubated for 10 mins followed by substrate addition and measured for 4 mins by spectrophotometric analysis | B | 6.97 | pIC50 | 108.1 | nM | IC50 | Eur J Med Chem (2021) 215: 113269-113269 [PMID:33588177] |
ChEMBL | Inhibition of rat kidney NADPH-dependent aldose reductase assessed as DL-glyceraldehyde conversion to glycerol preincubated for 20 mins followed by NADPH addition measured after 5 mins by UV-Visible spectrophotometric analysis | B | 7 | pIC50 | 100 | nM | IC50 | Eur J Med Chem (2014) 71: 53-66 [PMID:24275248] |
ChEMBL | Inhibition of rat lens ALR2 using D,L-glyceraldehyde as substrate assessed as decrease in NADPH oxidation preincubated for 10 mins followed by substrate addition measured for 4 mins by spectrophotometer | B | 7.07 | pIC50 | 86 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 887-892 [PMID:28109789] |
ChEMBL | Inhibition of Wistar rat ALR2 using D,L-glyceraldehyde as substrate assessed as oxidation of NADPH preincubated for 10 mins followed by substrate addition measured for 4 mins by spectrophotometric analysis | B | 7.07 | pIC50 | 85.68 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 3924-3927 [PMID:26227780] |
ChEMBL | Inhibition of Wistar rat lenses ALR2 using D,L-glyceraldehyde as substrate preincubated for 10 mins before substrate addition measured after 5 mins by spectrophotometry | B | 7.08 | pIC50 | 84 | nM | IC50 | J Med Chem (2015) 58: 1254-1267 [PMID:25602762] |
ChEMBL | Inhibition of AKR1B1 in rat lenses | B | 7.09 | pIC50 | 81 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 127101-127101 [PMID:32192796] |
ChEMBL | Inhibition of rat lens aldose reductase using DL-glyceraldehyde as substrate after 30 mins by fluorescence microplate reader analysis | B | 7.14 | pIC50 | 72 | nM | IC50 | Bioorg Med Chem (2012) 20: 832-840 [PMID:22209731] |
ChEMBL | Inhibition of aldose reductase in rat lens homogenates by fluorophotometer | B | 7.14 | pIC50 | 72 | nM | IC50 | J Nat Prod (2002) 65: 1151-1155 [PMID:12193020] |
ChEMBL | Inhibition of rat lens aldose reductase | B | 7.15 | pIC50 | 70 | nM | IC50 | J Nat Prod (2008) 71: 713-715 [PMID:18298080] |
ChEMBL | Inhibition of Sprague-Dawley rat lens aldose reductase | B | 7.17 | pIC50 | 67 | nM | IC50 | J Nat Prod (2012) 75: 267-270 [PMID:22264115] |
ChEMBL | Inhibition of rat lens ALR2 using D,L-glyceraldehyde as substrate preincubated for 5 mins at 30 degC followed by substrate addition and measured after 4 mins in presence of NADPH | B | 7.35 | pIC50 | 45 | nM | IC50 | Bioorg Med Chem (2020) 28: 115699-115699 [PMID:33069078] |
ChEMBL | DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) | B | 7.49 | pIC50 | 32 | nM | IC50 | DrugMatrix in vitro pharmacology data |
ChEMBL | Inhibition of Wistar rat lens ALR2 using L-glyceraldehyde as substrate preincubated for 10 mins followed by substrate addition and measured for 4 mins by spectrophotometric method | B | 7.51 | pIC50 | 31 | nM | IC50 | Bioorg Med Chem (2019) 27: 1658-1669 [PMID:30858026] |
ChEMBL | Inhibitory activity against purified rat lens aldose reductase (RLAR) | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (1994) 37: 787-792 [PMID:8145228] |
ChEMBL | In vitro inhibitory activity against partially purified rat lens Aldose reductase at a dose of 5e-7M | B | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (1996) 39: 1924-1927 [PMID:8627616] |
ChEMBL | Inhibitory activity against rat lens aldose reductase(AR). | B | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (1997) 40: 684-694 [PMID:9057855] |
ChEMBL | Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrate | B | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (1991) 34: 1011-1018 [PMID:1900532] |
ChEMBL | Inhibition of crude aldose reductase of rat lens | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (1986) 29: 2024-2028 [PMID:3093680] |
Sorbitol dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2275] [UniProtKB: Q00796] | ||||||||
ChEMBL | Inhibition sorbitol dehydrogenase by spectrophotometric analysis | B | 4.17 | pIC50 | 67700 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 5630-5633 [PMID:20805028] |
CYP4A11 in Human [GtoPdb: 1341] [UniProtKB: Q02928] | ||||||||
GtoPdb | - | - | 5.74 | pIC50 | 1820 | nM | IC50 | J Pharmacol Exp Ther (2018) 366: 446-457 [PMID:29976573] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]