ChEMBL ligand: CHEMBL119235
14-3-3 protein gamma in Human [ChEMBL: CHEMBL1293296] [UniProtKB: P61981] There should be some charts here, you may need to enable JavaScript!
14-3-3 protein zeta/delta in Human [ChEMBL: CHEMBL4105899] [UniProtKB: P63104] There should be some charts here, you may need to enable JavaScript!
P2X1/P2X purinoceptor 1 in Mouse [ChEMBL: CHEMBL5496] [GtoPdb: 478] [UniProtKB: P51576] P2X1/P2X purinoceptor 1 in Rat [ChEMBL: CHEMBL2530] [GtoPdb: 478] [UniProtKB: P47824] There should be some charts here, you may need to enable JavaScript!
P2X2/P2X purinoceptor 2 in Rat [ChEMBL: CHEMBL2135] [GtoPdb: 479] [UniProtKB: P49653] There should be some charts here, you may need to enable JavaScript!
P2X3/P2X purinoceptor 3 in Rat [ChEMBL: CHEMBL4824] [GtoPdb: 480] [UniProtKB: P49654] There should be some charts here, you may need to enable JavaScript!
P2X7/P2X purinoceptor 7 in Human [ChEMBL: CHEMBL4805] [GtoPdb: 484] [UniProtKB: Q99572] There should be some charts here, you may need to enable JavaScript!
P2Y purinoceptor 1 in Turkey [ChEMBL: CHEMBL5720] [UniProtKB: P49652] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
14-3-3 protein gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293296] [UniProtKB: P61981]
ChEMBL	Binding affinity to GST-tagged 14-3-3-gamma (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of interaction with PRAS40 in African green monkey COS7 cells preincubated with protein followed by cell addition by ELISA	B	4.79	pIC50	16400	nM	IC50	J Med Chem (2018) 61: 3755-3778 [PMID:28968506]
14-3-3 protein zeta/delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105899] [UniProtKB: P63104]
ChEMBL	Inhibition of PRAS40 binding to human GST-tagged 14-3-3 protein zeta/delta expressed in Escherichia coli BL21(DE3) by ELISA	B	5.03	pIC50	9300	nM	IC50	J Med Chem (2018) 61: 1276-1284 [PMID:29328660]
ChEMBL	Binding affinity to GST-tagged 14-3-3-zeta (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of interaction with PRAS40 in African green monkey COS7 cells preincubated with protein followed by cell addition by ELISA	B	5.03	pIC50	9300	nM	IC50	J Med Chem (2018) 61: 3755-3778 [PMID:28968506]
P2X1/P2X purinoceptor 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5496] [GtoPdb: 478] [UniProtKB: P51576]
ChEMBL	Antagonist activity at recombinant mouse P2X1 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current preincubated for 20 mins followed by ATP addition by two-electrode voltage clamp assay	B	7.52	pIC50	30	nM	IC50	Eur J Med Chem (2013) 70: 811-830 [PMID:24246730]
P2X1/P2X purinoceptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2530] [GtoPdb: 478] [UniProtKB: P47824]
ChEMBL	Antagonist activity at recombinant rat P2X1 receptor expressed in Xenopus oocytes assessed as ion flux stimulation	B	7.37	pIC50	43	nM	IC50	Eur J Med Chem (2013) 70: 811-830 [PMID:24246730]
GtoPdb	-	-	8	pIC50	~10	nM	IC50	J Med Chem (2001) 44: 340-9 [PMID:11462975]
ChEMBL	Inhibition of inward ion current elicited by ATP at P2X1 receptor expressed in Xenopus oocytes	F	8.03	pIC50	9.4	nM	IC50	J Med Chem (2001) 44: 340-349 [PMID:11462975]
P2X2/P2X purinoceptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2135] [GtoPdb: 479] [UniProtKB: P49653]
ChEMBL	Inhibition of inward ion current elicited by ATP at P2X2 receptor expressed in Xenopus oocytes	F	4.92	pIC50	11900	nM	IC50	J Med Chem (2001) 44: 340-349 [PMID:11462975]
P2X3/P2X purinoceptor 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4824] [GtoPdb: 480] [UniProtKB: P49654]
ChEMBL	Inhibition of inward ion current elicited by ATP was determined at recombinant P2X3 receptor expressed in Xenopus oocytes	F	6.85	pIC50	140	nM	IC50	J Med Chem (2001) 44: 340-349 [PMID:11462975]
P2X7/P2X purinoceptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4805] [GtoPdb: 484] [UniProtKB: Q99572]
ChEMBL	Antagonist activity at P2X7 receptor (unknown origin)	B	6.22	pIC50	600	nM	IC50	Bioorg Med Chem (2013) 21: 2643-2650 [PMID:23510563]
P2Y purinoceptor 1 in Turkey (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5720] [UniProtKB: P49652]
ChEMBL	Inhibition of 10 nM 2-MeS-ADP-stimulated phospholipase C in turkey erythrocyte membranes using [3H]inositol	F	4	pIC50	100000	nM	IC50	J Med Chem (2001) 44: 340-349 [PMID:11462975]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]