ChEMBL ligand: CHEMBL119235
14-3-3 protein gamma in Human [ChEMBL: CHEMBL1293296] [UniProtKB: P61981] There should be some charts here, you may need to enable JavaScript!
14-3-3 protein zeta/delta in Human [ChEMBL: CHEMBL4105899] [UniProtKB: P63104] There should be some charts here, you may need to enable JavaScript!
P2X1/P2X purinoceptor 1 in Mouse [ChEMBL: CHEMBL5496] [GtoPdb: 478] [UniProtKB: P51576] P2X1/P2X purinoceptor 1 in Rat [ChEMBL: CHEMBL2530] [GtoPdb: 478] [UniProtKB: P47824] There should be some charts here, you may need to enable JavaScript!
P2X2/P2X purinoceptor 2 in Rat [ChEMBL: CHEMBL2135] [GtoPdb: 479] [UniProtKB: P49653] There should be some charts here, you may need to enable JavaScript!
P2X3/P2X purinoceptor 3 in Rat [ChEMBL: CHEMBL4824] [GtoPdb: 480] [UniProtKB: P49654] There should be some charts here, you may need to enable JavaScript!
P2X7/P2X purinoceptor 7 in Human [ChEMBL: CHEMBL4805] [GtoPdb: 484] [UniProtKB: Q99572] There should be some charts here, you may need to enable JavaScript!
P2Y purinoceptor 1 in Turkey [ChEMBL: CHEMBL5720] [UniProtKB: P49652] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
14-3-3 protein gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293296] [UniProtKB: P61981]
ChEMBL	Binding affinity to GST-tagged 14-3-3-gamma (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of interaction with PRAS40 in African green monkey COS7 cells preincubated with protein followed by cell addition by ELISA	B	4.79	pIC50	16400	nM	IC50	J Med Chem (2018) 61: 3755-3778 [PMID:28968506]
14-3-3 protein zeta/delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105899] [UniProtKB: P63104]
ChEMBL	Inhibition of PRAS40 binding to human GST-tagged 14-3-3 protein zeta/delta expressed in Escherichia coli BL21(DE3) by ELISA	B	5.03	pIC50	9300	nM	IC50	J Med Chem (2018) 61: 1276-1284 [PMID:29328660]
ChEMBL	Binding affinity to GST-tagged 14-3-3-zeta (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of interaction with PRAS40 in African green monkey COS7 cells preincubated with protein followed by cell addition by ELISA	B	5.03	pIC50	9300	nM	IC50	J Med Chem (2018) 61: 3755-3778 [PMID:28968506]
P2X1/P2X purinoceptor 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5496] [GtoPdb: 478] [UniProtKB: P51576]
ChEMBL	Antagonist activity at recombinant mouse P2X1 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current preincubated for 20 mins followed by ATP addition by two-electrode voltage clamp assay	B	7.52	pIC50	30	nM	IC50	Eur J Med Chem (2013) 70: 811-830 [PMID:24246730]
P2X1/P2X purinoceptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2530] [GtoPdb: 478] [UniProtKB: P47824]
ChEMBL	Antagonist activity at recombinant rat P2X1 receptor expressed in Xenopus oocytes assessed as ion flux stimulation	B	7.37	pIC50	43	nM	IC50	Eur J Med Chem (2013) 70: 811-830 [PMID:24246730]
GtoPdb	-	-	8	pIC50	~10	nM	IC50	J Med Chem (2001) 44: 340-9 [PMID:11462975]
ChEMBL	Inhibition of inward ion current elicited by ATP at P2X1 receptor expressed in Xenopus oocytes	F	8.03	pIC50	9.4	nM	IC50	J Med Chem (2001) 44: 340-349 [PMID:11462975]
P2X2/P2X purinoceptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2135] [GtoPdb: 479] [UniProtKB: P49653]
ChEMBL	Inhibition of inward ion current elicited by ATP at P2X2 receptor expressed in Xenopus oocytes	F	4.92	pIC50	11900	nM	IC50	J Med Chem (2001) 44: 340-349 [PMID:11462975]
P2X3/P2X purinoceptor 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4824] [GtoPdb: 480] [UniProtKB: P49654]
ChEMBL	Inhibition of inward ion current elicited by ATP was determined at recombinant P2X3 receptor expressed in Xenopus oocytes	F	6.85	pIC50	140	nM	IC50	J Med Chem (2001) 44: 340-349 [PMID:11462975]
P2X7/P2X purinoceptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4805] [GtoPdb: 484] [UniProtKB: Q99572]
ChEMBL	Antagonist activity at P2X7 receptor (unknown origin)	B	6.22	pIC50	600	nM	IC50	Bioorg Med Chem (2013) 21: 2643-2650 [PMID:23510563]
P2Y purinoceptor 1 in Turkey (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5720] [UniProtKB: P49652]
ChEMBL	Inhibition of 10 nM 2-MeS-ADP-stimulated phospholipase C in turkey erythrocyte membranes using [3H]inositol	F	4	pIC50	100000	nM	IC50	J Med Chem (2001) 44: 340-349 [PMID:11462975]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]