ChEMBL ligand: CHEMBL4297588 (A-4250, A4250, AR-H064974, AZD-8294, AZD8294, Odevixibat)
Farnesoid X receptor/Bile acid receptor in Human [ChEMBL: CHEMBL2047] [GtoPdb: 603] [UniProtKB: Q96RI1] There should be some charts here, you may need to enable JavaScript!
Sodium/bile acid and sulphated solute cotransporter 2 in Human [GtoPdb: 960] [UniProtKB: Q12908] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Farnesoid X receptor/Bile acid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2047] [GtoPdb: 603] [UniProtKB: Q96RI1]
ChEMBL	Glycocholic acid Uptake Radiometric Assay: ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric¿SPA Inhibitor IC50 Mean IC50 (nM) was determined.	B	9.8	pIC50	0.16	nM	IC50	US-9694018-B1. IBAT inhibitors for the treatment of liver disease (2017)
Sodium/bile acid and sulphated solute cotransporter 2 in Human [GtoPdb: 960] [UniProtKB: Q12908]
GtoPdb	Inhibition of glycocholic acid uptake via hASBT in vitro.	-	9.8	pIC50	0.16	nM	IC50	US9694018B1. IBAT inhibitors for the treatment of liver disease (2017)

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]